A device for real-time, intraoperative margin assessment in breast-conservation surgery
A device for real-time, intraoperative margin assessment in breast-conservation surgery
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DOI：
10.1016/j.amjsurg.2007.06.013
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发表时间：
2007-10-01
影响因子：
3
通讯作者：
Lelcuk, Shlomo
中科院分区：
文献类型：
--
作者：
Karni, Tami;Pappo, Itzhak;Lelcuk, Shlomo
背景：本试验旨在研究新型手持式探头（Dune Medical Devices，凯撒利亚，以色列）在术中检测阳性切缘方面的性能及其对最大限度降低阳性切缘率的潜在益处。方法：术中将该探头应用于 57 个肿瘤切除标本。外科医生对设备输出不知情，手术决策不受探头数据的影响。将探针读数与每个边缘和每个患者的组织学分析进行比较。结果：22 名病理学阳性患者中的 19 名 (86%) 在术中使用设备检测到。每切缘敏感性为 0.71，特异性为 0.68，维持在阳性切缘定义范围内 (0-.4 cm)。结论：该设备是术中检测阳性切缘的有效工具，具有显着降低阳性切缘率的潜力。 (c) 2007 Excerpta Medica Inc. 保留所有权利。
Background: This trial was designed to study performance of a novel handheld probe (Dune Medical Devices, Caesarea, Israel) in intraoperative detection of positive margins and its potential benefit toward minimizing the positive margin rate.Methods: The probe was intraoperatively applied to 57 lumpectomy specimens. Surgeons were blinded to device output, and surgical decisions were not affected by probe data. Probe readings were compared with histological analysis per margin and per patient.Results: Nineteen of 22 (86%) pathology-positive patients were intraoperatively detected with device use. Per-margin sensitivity was .71, and specificity was .68, maintained within a range of positive margin definitions (0-.4 cm).Conclusions: The device is an effective tool for intraoperative detection of positive margins with the potential for significant positive margin rate reduction. (c) 2007 Excerpta Medica Inc. All rights reserved.