EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IN ALZHEIMERS-DISEASE
EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0022-510x(91)90202-i
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发表时间：
1991-11-01
影响因子：
4.4
通讯作者：
VANDENNOORT, S
中科院分区：
文献类型：
--
作者：
FROHMAN, EM;FROHMAN, TC;VANDENNOORT, S
本研究对13例临床和病理诊断为阿尔茨海默病的患者进行了细胞间黏附分子-1(ICAM-I)、ICAM-2、淋巴细胞功能相关抗原-1(LFA-1)、人类白细胞抗原-DR(HLA-DR)、层粘连蛋白-1(LN-1)和层粘连蛋白-2(LN-2)的检测。ICAM-1主要表达于神经炎性斑块和脑血管内皮细胞。ICAM-1在14例正常脑组织中也有表达；然而，与阿尔茨海默病患者相比，ICAM-1的免疫反应程度较低，主要局限于脑血管内皮细胞。LFA-1表达于小胶质细胞和白细胞。与以往报道的结果一致，发现小胶质细胞表达人类白细胞抗原-DR。在这项研究中，我们未能证明ICAM-1和LFA-1，ICAM-1和HLA-DR，或ICAM-1和LN-2的双重免疫定位。由于小胶质细胞同时表达HLA-DR和LFA-1，它们可能通过与淋巴细胞ICAM-1相互作用来介导抗原递呈功能。或者，这些免疫相关糖蛋白在胶质细胞上的表达可能是继发于疾病过程的某些方面的表象。最后，ICAM-1在神经突起斑块中的存在提出了一个问题，即黏附是否在轴突生长和神经变性过程中发挥了一定的作用。
In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-I), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.