Fetal death and congenital malformation in babies born to nuclear industry employees: report from the nuclear industry family study
Fetal death and congenital malformation in babies born to nuclear industry employees: report from the nuclear industry family study
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DOI：
10.1016/s0140-6736(00)02812-9
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发表时间：
2000-10-14
期刊：
影响因子：
168.9
通讯作者：
Beral, V
中科院分区：
文献类型：
--
作者：
Doyle, P;Maconochie, N;Beral, V
研究背景人们对暴露于低水平电离辐射的遗传效应有一些担忧，但证据稀少且相互矛盾。大多数工作都集中在后代的癌症，很少有做了不良生殖结果。我们的目的是评估是否后代的男性和女性谁是职业暴露于电离辐射的胎儿死亡和先天性畸形的风险增加。方法我们分析了怀孕的职业队列的核工业工人在英国，受雇于机构经营的原子能管理局，原子武器机构，英国核燃料。就业和辐射监测数据提供的雇主被链接到每个pregnancy.Findings 11 697名男性和1903名女性报告一个或多个单胎怀孕后，第一次就业的核工业，男性报告的23 676单胎怀孕和妇女3585。胎儿死亡和先天畸形的风险与父亲在怀孕前是否接受过监测或接受的辐射剂量无关。在妇女报告的怀孕中，早期（
Background There is some concern about the genetic effects of exposure to low-level ionising radiation, but the evidence is sparse and conflicting. Most work has concentrated on cancer in offspring and little has been done on adverse reproductive outcome. We aimed to assess whether the offspring of men and women who are occupationally exposed to ionising radiation are at increased risk of fetal death and congenital malformation.Methods We analysed pregnancies reported by an occupational cohort of nuclear industry workers in the UK, employed at establishments operated by the Atomic Energy Authority, Atomic Weapons Establishment, and British Nuclear Fuels. Employment and radiation monitoring data supplied by employers was linked to each pregnancy.Findings 11 697 men and 1903 women reported one or more singleton pregnancy conceived after first employment within the nuclear industry, the men reporting a total of 23 676 singleton pregnancies and the women 3585. The risks of fetal death and congenital malformation were not related to whether the father had been monitored before conception or to the dose of radiation received. Among pregnancies reported by women, the risk of early (