High-Intensity Drinking in Adult Australian Twins
High-Intensity Drinking in Adult Australian Twins
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DOI：
10.1111/acer.14262
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发表时间：
2020-01-13
影响因子：
3.2
通讯作者：
Slutske, Wendy S.
中科院分区：
文献类型：
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作者：
Dash, Genevieve F.;Davis, Christal N.;Slutske, Wendy S.
许多成年饮酒者的饮酒量远远超过了狂欢的阈值。这种“高强度饮酒”（HID），定义为狂欢阈值的2倍（HID-2）和3倍（HID-3），由于其在急性酒精相关危害中的作用而引起公共卫生利益。对HID的研究大多局限于大学年龄的年轻人，关注环境因素，而忽视了遗传影响对参与HID倾向的潜在作用。方法对3785人（1365名男性，2420名女性，m -年龄= 32岁，范围= 21 - 46岁）进行结构化诊断访谈，评估过去一年的饮酒情况，包括来自澳大利亚双胞胎登记处的3314名双胞胎和471名非双胞胎兄弟姐妹。进行多项逻辑回归分析，比较HID-2和HID-3与酗酒的人口学相关性、饮酒特征和饮酒相关后果。采用生物识别模型来估计遗传、常见和个体特异性环境因素在HID倾向中的作用。结果在过去一年的饮酒者中，HID-2和HID-3的患病率均为22%，其中男性比例不成比例。在重度饮酒者中，饮酒、醉酒和狂饮的频率显著增加，这也证明了更高的平均消费量和更高的酒精相关后果发生率。参与HID的倾向具有显著的遗传性（A = 37% [95% CI: 28至46%]），个体特定的环境影响解释了剩余的方差。本研究令人信服地表明，HID不仅限于大学年龄的年轻人，而且在工作年龄的人群中也非常普遍，并且参与HID的倾向部分可以通过遗传影响来解释。
Background Many adult drinkers consume far beyond the binge threshold. This "high-intensity drinking" (HID), defined as 2 (HID-2) and 3 (HID-3) times the binge threshold, is of public health interest due to its role in acute alcohol-related harms. Research on HID has mostly been limited to college-aged young adults, focused on contextual factors, and neglected the potential role of genetic influences on the propensity to engage in HID. Methods Structured diagnostic interviews assessing past-year alcohol involvement were conducted with 3,785 individuals (1,365 men, 2,420 women; M-age = 32, range = 21 to 46), including 3,314 twins and 471 nontwin siblings from the Australian Twin Registry. Multinomial logistic regression analyses were conducted to compare HID-2 and HID-3 to binge drinking on demographic correlates, drinking characteristics, and drinking-related consequences. Biometric modeling was conducted to estimate the role of genetic, common, and individual-specific environmental factors in HID propensity. Results Among past-year drinkers, the prevalence of HID-2 and HID-3 was both 22%, with men disproportionally represented. The frequencies of drinking, intoxication, and binge drinking significantly increased across the heavier drinking categories, which also evidenced higher average consumption quantities and higher rates of alcohol-related consequences. The propensity to engage in HID was significantly heritable (A = 37% [95% CI: 28 to 46%]), with individual-specific environmental influences accounting for the remainder of the variance. Conclusions This study convincingly demonstrates that HID is not restricted to college-aged young adults, but also can be highly prevalent among those of working age, and that the propensity to engage in HID is partially explained by genetic influences.