Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.
Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.
复制标题
植物膳食补充剂中的毒素：蓝升麻成分会破坏细胞呼吸和线粒体膜电位。
DOI：
10.1021/np400758t
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发表时间：
2014
影响因子：
5.1
通讯作者：
Zhou,Yu-Dong
中科院分区：
文献类型：
--
作者：
Datta,Sandipan;Mahdi,Fakhri;Ali,Zulfiqar;Jekabsons,MikaB;Khan,IkhlasA;Nagle,DaleG;Zhou,Yu-Dong
某些植物膳食补充剂与特异性器官毒性有关。由药物诱导的线粒体功能障碍引起的类似毒理学事件，已经迫使主要药物的撤回或美国FDA“黑匣子”警告。为了评估植物膳食补充剂的潜在线粒体责任，评估了传统中国，阿育吠陀和西方草药中使用的352种经过认证的植物样品的提取物破坏细胞呼吸的能力。蓝升麻甲醇提取物具有一定的生物活性。一些美国助产士使用蓝升麻来帮助引产，蓝升麻与围产期中风、急性心肌梗死、充血性心力衰竭、多器官损伤和新生儿休克有关。线粒体破坏和特异质中草药中毒之间的潜在联系促使了进一步的研究。C.三种皂苷（cauloside A（1）、皂苷PE（2）和cauloside C（3））具有浓度和时间依赖性的抗肿瘤活性。在处理后，细胞呼吸速率迅速增加，然后在几分钟内急剧下降。机理研究表明，C. thalictroides成分通过破坏膜完整性损害线粒体功能。这些研究提供了一个潜在的病因之间的联系，这种敏感形式的细胞毒性和特异质器官损伤。
Certain botanical dietary supplements have been associated with idiosyncratic organ-specific toxicity. Similar toxicological events, caused by drug-induced mitochondrial dysfunction, have forced the withdrawal or U.S. FDA “black box” warnings of major pharmaceuticals. To assess the potential mitochondrial liability of botanical dietary supplements, extracts from 352 authenticated plant samples used in traditional Chinese, Ayurvedic, and Western herbal medicine were evaluated for the ability to disrupt cellular respiration. Blue cohosh (Caulophyllum thalictroides) methanol extract exhibited mitochondriotoxic activity. Used by some U.S. midwives to help induce labor, blue cohosh has been associated with perinatal stroke, acute myocardial infarction, congestive heart failure, multiple organ injury, and neonatal shock. The potential link between mitochondrial disruption and idiosyncratic herbal intoxication prompted further examination. TheC. thalictroidesmethanol extract and three saponins, cauloside A (1), saponin PE (2), and cauloside C (3), exhibited concentration- and time-dependent mitochondriotoxic activities. Upon treatment, cell respiration rate rapidly increased and then dramatically decreased within minutes. Mechanistic studies revealed thatC. thalictroidesconstituents impair mitochondrial function by disrupting membrane integrity. These studies provide a potential etiological link between this mitochondria-sensitive form of cytotoxicity and idiosyncratic organ damage.