Monoterpenoid Indole Alkaloids from Gardneria ovata
Monoterpenoid Indole Alkaloids from Gardneria ovata
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卵形栀子中的单萜吲哚生物碱
DOI：
10.1021/np2000254
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发表时间：
2011-05-01
影响因子：
5.1
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Li, Xiao-Ning;Cai, Xiang-Hai;Luo, Xiao-Dong
从大蒜中分离得到8个新的单萜类吲哚生物碱，分别为栀子胺-9-O-β-D-吡喃葡萄糖苷(1)，19(E)-18-去甲氧基栀子胺-N(4)氧化物(2)，Gardfloramine-N(4)-氧化物(3)，18-去甲基栀子胺(4)，19(E)-9，18-二去甲氧基栀子胺(5)，19(E)-11-甲氧基-9，18-二甲氧基栀子胺(6)，9-去甲基-18-去甲氧基栀子胺(7)和米非司汀-N(4)氧化物(8)，以及6个已知生物碱。用波谱方法确定了新生物碱的结构。这些化合物对五种人类癌细胞株都没有细胞毒性。
Eight new monoterpenoid indole alkaloids, gardfloramine-9-O-beta-D-glucopyranoside (1), 19(E)-18-demethoxygardfloramine-N(4)oxide (2), gardfloramine-N(4)-oxide (3), 18-demethylgardfloramine (4), 19 (E)-9,18-didemethoxygardneramine (5), 19(E)-11-methoxy-9,18-didemethoxygardneramine (6), 9-demethoxy-18-demethylgardneramine (7), and minfiensine-N(4)-oxide (8), along with six known alkaloids, were isolated from Gardneria ovata. The structures of the new alkaloids were established by means of spectroscopic methods. None of the compounds were cytotoxic to five human cancer cell lines.