Association of cognitive restraint with ghrelin, leptin, and insulin levels in subjects who are not weight-reduced
Association of cognitive restraint with ghrelin, leptin, and insulin levels in subjects who are not weight-reduced
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DOI：
10.1016/j.physbeh.2007.11.025
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发表时间：
2008-03-18
影响因子：
2.9
通讯作者：
Foster-Schubert, Karen E.
中科院分区：
文献类型：
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作者：
Schur, Ellen A.;Cummings, David E.;Foster-Schubert, Karen E.
尽管人们在减肥方面做出了广泛的努力，但肥胖的患病率仍在上升。节制饮食是一种试图控制体重的模式，其特征是对食物摄入的认知限制，这与暴饮暴食和/或体重增加有矛盾的联系。目前尚不清楚节制饮食是否与食欲调节激素的异常有关，而与它对体重的影响无关。为了解决这个问题，我们使用三因素饮食问卷评估了认知约束，并获得了24名健康、非肥胖（体重指数（BMI） 19.7至29.6 kg/m(2)）成人受试者的饥饿素、瘦素和胰岛素的空腹测量值，这些受试者处于稳定的一生最大体重。我们选择稳定最大体重的研究对象，以避免体重减轻对体重调节激素的二次影响。根据认知约束量表得分将受试者分为低约束组、不确定组和高约束组。在未调整的模型中（P=0.004）和调整BMI后（P=0.007），较高的胃饥饿素水平与约束显著相关。约束评分与瘦素（P=0.75）和胰岛素（P=0.36）均无相关性。这些发现表明，节制饮食者体内的促氧激素水平与体重变化无关。(c) 2007爱思唯尔公司版权所有。
Despite widespread efforts at weight loss, the prevalence of obesity continues to rise. Restrained eating is a pattern of attempted weight control characterized by cognitive restriction of food intake that has paradoxically been linked with overeating and/or weight gain. It is not known whether restrained eating is associated with abnormalities in appetite-regulating hormones, independent of its effects on body weight. To address this question, we assessed cognitive restraint using the Three-Factor Eating Questionnaire and obtained fasting measurements of ghrelin, leptin and insulin from 24 healthy, non-obese (body mass index (BMI) 19.7 to 29.6 kg/m(2)) adult subjects who were at a stable, lifetime maximum weight. We chose to study subjects at stable maximum weight to avoid the secondary effects of weight reduction on body-weight regulating hormones. Subjects were classified by cognitive restraint scale score into Low, Indeterminate, and High Restraint groups. Higher ghrelin levels were significantly associated with restraint in an unadjusted model (P=0.004) and after adjustment for BMI (P=0.007). No relationships were found between restraint scores and either leptin (P=0.75) or insulin (P=0.36). These findings show an orexigenic hormonal profile in restrained eaters, independent of changes in body weight. (c) 2007 Elsevier Inc. All rights reserved.