Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients
Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients
复制标题
急性中风患者与心房颤动相关的各种牙周病原体血清 IgG 滴度的评估
DOI：
10.1016/j.jstrokecerebrovasdis.2021.106301
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发表时间：
2022
影响因子：
2.5
通讯作者：
Maruyama Hirofumi
中科院分区：
文献类型：
--
作者：
Nezu Tomohisa;Hosomi Naohisa;Aoki Shiro;Nishi Hiromi;Nakamori Masahiro;Shiga Yuji;Imamura Eiji;Shintani Tomoaki;Kawaguchi Hiroyuki;Maruyama Hirofumi
ObjectivesThere是越来越多的证据表明，牙周病与心房颤动（AF）或中风，但目前还不清楚，牙周病的致病物种是目前在中风患者AF。我们的目的是调查AF和特定的牙周病原体之间的关联使用血清效价的IgG抗体的细菌在急性中风patients.Materials和methodsAcute中风患者在两家医院登记。血清样本进行了评价，对9牙周病原体（16种基因型）的抗体滴度使用ELISAs。我们根据以下标准确定患者的AF：（1）持续性或阵发性AF病史或（2）到达时或入院时检测到AF。结果664例急性脑卒中患者中，有123例（18.5%）患有房颤，经过倾向评分匹配，选出234例患者。房颤患者血清牙龈卟啉单胞菌抗体阳性率较高（FimA III型）和牙龈卟啉单胞菌（FimA V型）比无AF的患者（59.0%vs.39.3%，p =0.004和58.2%vs.40.2%，p =0.009）。可能与中风患者的房颤有关。
ObjectivesThere is accumulating evidence that periodontal disease is associated with atrial fibrillation (AF) or stroke, but it is unclear which causative species of periodontal disease are present in stroke patients with AF. We aimed to investigate the associations between AF and specific periodontal pathogens using serum titers of IgG antibodies of bacteria in acute stroke patients.Materials and methodsAcute stroke patients were registered at two hospitals. Serum samples were evaluated for titers of antibodies against 9 periodontal pathogens (16 genotypes) using ELISAs. We identified AF in patients according to the following criteria: (1) a history of sustained or paroxysmal AF or (2) AF detection upon arrival or during admission. We carried out propensity score matching to categorize the patients as those with AF and those without.ResultsOf the 664 acute stroke patients, 123 (18.5%) had AF. After propensity score matching, 234 patients were selected. Patients with AF had a higher prevalence of positive serum titers of antibodies againstPorphyromonas gingivalis(FimA type III) andPorphyromonas gingivalis(FimA type V) than those without AF (59.0% vs. 39.3%, p=0.004 and 58.2% vs. 40.2%, p=0.009, respectively).ConclusionsPorphyromonas gingivalis,especially FimA type III and type V, might be associated with AF in stroke patients.