Hepatitis G virus infection in a haemodialysis unit: Prevalence and clinical implications
Hepatitis G virus infection in a haemodialysis unit: Prevalence and clinical implications
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DOI：
10.1093/ndt/12.5.956
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发表时间：
1997-05-01
影响因子：
6.1
通讯作者：
Rodes, J
中科院分区：
文献类型：
--
作者：
Forns, X;FernandezLlama, P;Rodes, J
背景。肝炎病毒已成为长期血液透析患者的主要感染问题之一。最近发现了一种新的 RNA 病毒，称为 G 型肝炎病毒 (HGV)。目前正在调查该病毒的致病相关性。本研究的目的是分析血液透析患者中庚型肝炎病毒感染的患病率及其临床意义。方法。在 96 名维持性血液透析患者中研究了 HGV-RNA 的存在。对所有这些患者进行了肝炎病毒标志物（HBsAg、抗 HCV、HGV-RNA）和肝脏检查以及肝炎病毒感染的危险因素评估。作为对照组，对 200 名献血者进行了 HGV-RNA 检测。结果。在 96 名血液透析患者中的 25 名（26%）和 200 名献血者中的 6 名（3%）中检测到 HGV-RNA（P < 0.001）。 25 名 HGV 感染患者中有 13 名 (52%) 合并感染其他肝炎病毒（HBV 和/或 HCV）。感染 HBV 和/或 HCV 的患者 (61%) 比仅感染 HGV 的患者 (17%) 更容易出现慢性肝病 (P = 0.01)。尽管80%的HGV感染患者接受过血液制品，但输血率与非HGV感染患者没有差异。与感染 HBV 和/或 HCV 的患者（7.6 +/- 5.8 年）相比，仅感染 HGV 的患者的血液透析时间（3.1 +/- 3.5 年）显着缩短（P = 0.04）。结论。维持性血液透析患者感染 HGV 的风险增加。 HGV 感染本身似乎并不是这些患者慢性肝病的常见原因。由于献血者中 HGV 感染率较高，输血可能是血液透析患者 HGV 传播的主要因素之一。
Background. Hepatitis viruses have become one of the main infectious problems in patients on long-term haemodialysis. A new RNA virus, designated hepatitis G virus (HGV) has been recently identified. The pathogenic relevance of this virus is currently under investigation. The aim of this study was to analyse the prevalence and clinical implications of hepatitis G virus infection in patients on haemodialysis.Methods. The presence of HGV-RNA was investigated in 96 patients on maintenance haemodialysis. Hepatitis viral markers (HBsAg, anti-HCV, HGV-RNA) and liver tests were assessed in all these patients, as well as the risk factors for hepatitis viruses acquisition. as a control group, 200 blood donors were tested for the presence of HGV-RNA.Results. HGV-RNA was detected in 25 of 96 patients on haemodialysis (26%) and in six of 200 blood donors (3%) (P < 0.001). Thirteen of 25 HGV infected patients (52%) were coinfected with other hepatitis viruses (HBV and/or HCV). Evidences of chronic liver disease were more frequent in patients infected by HBV and/or HCV (61%) than in patients infected by HGV alone (17%) (P = 0.01). Although 80% of HGV infected patients had received blood products, the transfusion rate was not different from non HGV-infected patients. Time on haemodialysis was significantly shorter in patients infected with HGV alone (3.1 +/- 3.5 years) compared to patients infected with HBV and/or HCV (7.6 +/- 5.8 years) (P = 0.04).Conclusions. Patients on maintenance haemodialysis are at increased risk for HGV infection. HGV infection itself does not seem to be a frequent cause of chronic liver disease in these patients. Since the prevalence of HGV infection in blood donors is high, blood transfusion could be one of the main factors implicated in HGV transmission in patients on haemodialysis.