Exposure to a cat produces opioid analgesia in rats.
Exposure to a cat produces opioid analgesia in rats.
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与猫接触会对大鼠产生阿片类镇痛作用。
DOI：
10.1037//0735-7044.99.4.756
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发表时间：
1985
影响因子：
1.9
通讯作者：
Fanselow,MS
中科院分区：
文献类型：
--
作者：
Lester,LS;Fanselow,MS
两个实验测试了大鼠在猫存在的情况下对伤害性刺激的敏感性/反应性降低的预测。在将90只雌性Sprague-Dawley大鼠暴露于无刺激、新刺激或猫之前，向其腹膜内施用（110 mg/kg）或盐水。50只雄性大鼠给予生理盐水或纳洛酮（7 mg/kg），并暴露于无刺激物或猫。在这两个实验中，在猫存在下测试的大鼠对皮肤刺激性福尔马林注射液的敏感性/反应性显着降低。纳洛酮逆转了这种镇痛作用，而纳洛酮仅产生了较短的镇痛作用的微弱趋势。研究结果进行了讨论，由RC Bolles和第二作者提出的感知防御恢复模型（见记录1981-25138-001），它描绘了恐惧和疼痛作为竞争的动机系统，服务于不同的生物功能。(19参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Two experiments tested the prediction that rats should react with reduced sensitivity/reactivity to nociceptive stimulation in the presence of a cat. In Exp I, naloxone (110 mg/kg) or saline was administered intraperitoneally to 90 female Sprague-Dawley rats before they were exposed to no stimulus, a novel stimulus, or a cat. In Exp II, 50 male rats were administered saline or naltrexone (7 mg/kg) and were exposed to either no stimulus or a cat. In both experiments, rats tested in the presence of the cat showed a significant reduction in sensitivity/reactivity to a skin-irritating formalin injection. Naltrexone reversed this analgesia, while naloxone produced only a weak trend toward shorter latencies. Findings are discussed in relation to the perceptual-defensive-recuperative model presented by RC Bolles and the 2nd author (see record 1981-25138-001), which depicts fear and pain as competing motivational systems that serve different biological functions.(19 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)