Relation between radionuclide angiographic regional ejection fraction and left ventricular regional ischemia in awake dogs.
Relation between radionuclide angiographic regional ejection fraction and left ventricular regional ischemia in awake dogs.
复制标题
清醒犬放射性核素血管造影区域射血分数与左心室局部缺血的关系。
DOI：
10.1016/0002-9149(84)90442-9
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Cobb,FR
中科院分区：
文献类型：
--
作者：
Schneider,RM;Roberts,KB;Morris,KG;Stanfield,JA;Cobb,FR
采用多门控平衡放射性核素血管造影术对26只清醒犬在左前降支（LAD）或左旋支（LC）冠状动脉远端和近端闭塞10分钟后的整体和局部射血分数（EF）进行定量。全球和区域EF的变化与放射性同位素标记微球测量的急性左心室（LV）缺血程度的同时测量相关。缺血的程度，定义为左室质量的百分比与正常区域血流减少> 25%，与LAD（r = 0.84）和LC（r = 0.77）闭塞后总体EF的百分比变化呈线性相关。缺血程度也与局部EF相关（对于LAD，r = 0.47至0.88;对于LC闭塞，r = 0.41至0.69）。在25例LAD闭塞中的24例和所有20例产生可测量缺血区的LC闭塞中，局部EF的最大百分比变化超过了整体EF的百分比变化。两个左前降支闭塞和2 LC闭塞减少区域EF，但不是全球EF。因此，全球和区域EF下降成正比的程度急性心肌缺血，区域缺血产生更大的变化，区域比全球EF。
Multigated equilibrium radionuclide angiography was used to quantitate global and regional ejection fraction (EF) in 26 awake dogs 10 minutes after distal and then proximal occlusion of the left anterior descending (LAD) or left circumflex (LC) coronary artery. Changes in global and regional EF were correlated with simultaneous measurements of the extent of acute left ventricular (LV) ischemia measured by radioisotope-labeled microspheres. The extent of ischemia, defined as the percentage of LV mass with > 25 % reduction in blood flow from normal regional flow, was linearly related to the percent change in global EF after LAD (r = 0.84) and LC (r = 0.77) occlusions. The extent of ischemia also correlated with regional EF (r = 0.47 to 0.88 for LAD and r = 0.41 to 0.69 for LC occlusions). In 24 of 25 LAD occlusions and in all 20 LC occlusions that produced a measurable ischemic zone, the maximal percent change in regional EF exceeded the percent change in global EF. Two LAD occlusions and 2 LC occlusions reduced regional EF but not global EF.Thus, global and regional EF decreased in direct proportion to the extent of acute myocardial ischemia; regional ischemia produced greater changes in regional than in global EF.