Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue.
Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue.
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垂体激素调节淋巴组织中的 c-myc 和 DNA 合成。
DOI：
10.4049/jimmunol.146.7.2201
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发表时间：
1991
影响因子：
4.4
通讯作者：
H. Friesen
中科院分区：
文献类型：
--
作者：
I. Bérczi;É. Nagy;S. M. de Toledo;R. Matusik;H. Friesen
Fischer 344大鼠的两性垂体切除术导致胸腺和脾脏迅速退化，这与这些器官中自发DNA合成的严重减少有关。脾脏B淋巴细胞比例、脾脏和胸腺T细胞及其亚群（CD4+/CD8+）比例、受累脏器组织结构均正常。用生长激素（GH）或催乳素（PRL）治疗垂体切除的动物，刺激了c-myc原癌基因的表达和DNA的合成，逆转了这些器官的退化。促肾上腺皮质激素、促卵泡激素、促黄体生成素或促甲状腺激素的替代剂量对胸腺或脾脏大小和DNA合成没有影响。在注射GH或PRL后，c-myc在正常大鼠胸腺和脾脏中快速表达。体外生理浓度（2.5 ng/ml）的羊或大鼠PRL或GH均能刺激胸腺和脾脏细胞对[3H]胸腺嘧啶的掺入。这些结果表明GH和PRL调节淋巴细胞的生长。这种调节作用可能是这些激素调节免疫的主要机制。
Hypophysectomy of Fischer 344 rats of both sexes led to a rapid involution of the thymus and spleen which was associated with a profound decrease in spontaneous DNA synthesis in these organs. The proportion of B lymphocytes in the spleen, of T cells and their subsets (CD4+/CD8+) in spleen and thymus, and the histological structure of the involuted organs remained normal. Treatment of hypophysectomized animals with growth hormone (GH) or prolactin (PRL) stimulated the expression of the c-myc proto-oncogene and DNA synthesis and reversed the involution in these organs. Replacement doses of adrenocorticotrophic hormone, follicle-stimulating hormone, luteinizing hormone, or thyroid-stimulating hormone had no influence on thymus or spleen size and DNA synthesis. A rapid expression of c-myc was also observed in thymuses and spleens of intact rats after the injection of GH or PRL. In vitro physiological concentrations (2.5 ng/ml) of either ovine or rat PRL or GH stimulated the incorporation of [3H]thymidine by thymus and spleen cells. These results indicate that GH and PRL regulate lymphocyte growth. This regulatory role is likely to serve as the principal mechanism of immunoregulation by these hormones.