Separate neural bases of two fundamental memory processes in the human medial temporal lobe
Separate neural bases of two fundamental memory processes in the human medial temporal lobe
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DOI：
10.1126/science.276.5310.264
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发表时间：
1997-04-11
期刊：
影响因子：
56.9
通讯作者：
Glover, GH
中科院分区：
文献类型：
--
作者：
Gabrieli, JDE;Brewer, JB;Glover, GH
内侧颞叶结构在记忆表现中的参与通过局部血氧水平依赖信号的功能性磁共振成像来检查。在编码到记忆中的复杂场景或线条画，并在检索以前研究过的线条画或单词的记忆信号进行了测量。编码任务产生了增加的信号，不熟悉的信息在后内侧颞区，集中在海马旁皮质。检索任务产生了增加的信号，成功地记住了信息的前内侧颞区，集中在下托。这些结果表明，人类内侧颞叶记忆系统的独立组件在不同的记忆过程中是活跃的。
The participation of medial temporal-lobe structures in memory performance was examined by functional magnetic resonance imaging of local blood oxygenation level-dependent signals. Signals were measured during encoding into memory complex scenes or line drawings and during retrieval from memory of previously studied line drawings or words. Encoding tasks yielded increased signals for unfamiliar information in a posterior medial-temporal region that were focused in the parahippocampal cortex. Retrieval tasks yielded increased signals for successfully remembered information in an anterior medial-temporal region that were focused in the subiculum. These results indicate that separate components of the human medial temporal-lobe memory system are active during distinct memory processes.