Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms.
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms.
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DOI：
10.1016/j.abb.2009.01.018
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发表时间：
2009-06-15
影响因子：
3.9
通讯作者：
Kim AL
中科院分区：
文献类型：
--
作者：
Athar M;Back JH;Kopelovich L;Bickers DR;Kim AL
Plant-derived polyphenolic compounds, such as the stilbene resveratrol (trans-3, 4’, 5-trihydroxystilbene), have been identified as potent anti-cancer agents. Extensive in vitro studies revealed multiple intracellular targets of resveratrol, which affect cell growth, inflammation, apoptosis, angiogenesis, and invasion and metastasis. These include tumor suppressors p53 and Rb; cell cycle regulators, cyclins, CDKs, p21WAF1, p27KIP and INK and the checkpoint kinases ATM/ATR; transcription factors NF-κB, AP-1, c-Jun, and c-Fos; angiogenic and metastatic factors, VEGF and matrix metalloprotease 2/9; cyclooxygenases for inflammation; and apoptotic and survival regulators, Bax, Bak, PUMA, Noxa, TRAIL, APAF, survivin, Akt, Bcl-2 and Bcl-XL. In addition to its well-documented anti-oxidant properties, there is increasing evidence that resveratrol exhibits pro-oxidant activity under certain experimental conditions, causing oxidative DNA damage that may lead to cell cycle arrest or apoptosis. This review summarizes in vitro mechanistic data available for resveratrol and discusses new potential anti-cancer targets and the anti-proliferative mechanisms of resveratrol.
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影响因子：
3.5
作者：
Ami, AS;Bhat, SH;Hadi, SM
通讯作者：
Hadi, SM
影响因子：
3.8
作者：
Bhat, S. H.;Azmi, A. S.;Hadi, S. M.
通讯作者：
Hadi, S. M.
影响因子：
4.8
作者：
Bidère, N;Lorenzo, HK;Senik, A
通讯作者：
Senik, A
DOI：
10.1006/bbrc.2001.5819
发表时间：
2001-11-02
影响因子：
3.1
作者：
Adhami, VM;Afaq, F;Ahmad, N
通讯作者：
Ahmad, N
影响因子：
3.1
作者：
AUSPRUNK, DH;FOLKMAN, J
通讯作者：
FOLKMAN, J