Antibacterial properties of lidocaine on bacteria isolated from dermal lesions.
Antibacterial properties of lidocaine on bacteria isolated from dermal lesions.
复制标题
利多卡因对从真皮病变中分离出的细菌的抗菌特性。
DOI：
10.1001/archderm.1985.01660090071016
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发表时间：
1985
影响因子：
--
通讯作者：
W. Shelley
中科院分区：
文献类型：
--
作者：
M. Miller;W. Shelley
我们使用从皮肤病变中分离出的细菌研究了利多卡因和利多卡因与对羟基苯甲酸甲酯的抗菌特性。我们的研究是有意义的，因为在获得活检和/或培养材料之前使用局部麻醉剂可能导致假阴性结果。计算杀灭曲线，以确定细菌暴露于不同浓度的利多卡因（含和不含对羟基苯甲酸甲酯）的时间，这些时间可能影响临床标本中活菌的回收率。所研究的细菌对利多卡因的敏感性差异很大，其中奈瑟氏菌属最敏感。当存在对羟基苯甲酸甲酯时，注意到对细菌的更大的抑制活性。我们的研究表明，应采用不含尼泊金甲酯的低浓度利多卡因。
We studied the antibacterial properties of lidocaine and lidocaine with methylparaben, employing bacteria that were isolated from dermal lesions. Our study was significant because local anesthetics utilized before obtaining material for biopsy and/or culture may result in false-negative results. Killing curves were calculated to ascertain exposure times of bacteria to various concentrations of lidocaine with and without methylparaben that could affect recovery of viable bacteria from clinical specimens. The bacteria studied varied greatly in their susceptibility to lidocaine, with Neisseria species being the most sensitive. Greater inhibitory activity was noted against bacteria when methylparaben was present. Our study suggests that lower concentrations of lidocaine without methylparaben should be employed.