Blood pressure responses to acute stress and left ventricular mass (The Hypertension Genetic Epidemiology Network Study).
Blood pressure responses to acute stress and left ventricular mass (The Hypertension Genetic Epidemiology Network Study).
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血压对急性应激和左心室质量的反应（高血压遗传流行病学网络研究）。
DOI：
10.1016/s0002-9149(01)02305-0
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Arnett,DonnaK
中科院分区：
文献类型：
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作者：
al'Absi,Mustafa;Devereux,RichardB;Lewis,CoraE;Kitzman,DalaneW;Rao,DabeeruC;Hopkins,Paul;Markovitz,Jerome;Arnett,DonnaK
左心室肥大是心血管疾病发病的主要危险因素。本研究在一个大样本的中年高血压男性和女性中检测了血压反应性与左室质量和相对室壁厚度（RWT）的相关程度。参与者包括1，012名非洲裔美国人和655名高加索人，他们被招募参加高血压遗传流行病学网络（HyperGEN）研究。实验室压力协议的实施，包括BP测量在休息，握，心算应激源。随后进行二维引导M型超声心动图评价，以测量LV质量。非裔美国人的左心室质量大于白人（p <0.01）。在非裔美国人（p <0.001）和白人女性（p <0.0001）中，静息时收缩压与左室质量和RWT呈正相关。比较了参与者的LV质量和RWT，并根据参与者对2种实验室压力源的收缩压反应将其分为高反应者或低反应者。RWT表现出积极的协会与收缩压的反应，这两个任务。与左心室质量的关联大多不显着，除了在非裔美国人中收缩压对算术任务的反应与左心室质量之间存在负相关。我们的结论是，在这个高血压中年男性和女性队列中，BP反应性并不能预测LV质量。收缩压反应与RWT的正相关性表明，过度的反应可能特别与受血管紧张性影响的LV变化有关。
Left ventricular (LV) hypertrophy is a major risk factor for cardiovascular morbidity. This study examined the extent to which exaggerated blood pressure (BP) reactivity is associated with LV mass and relative wall thickness (RWT) in a large sample of middle-aged hypertensive men and women. Participants included 1,012 African-Americans and 655 Caucasians recruited for the Hypertension Genetics Epidemiology Network (HyperGEN) study. A laboratory stress protocol was implemented, consisting of BP measurement during rest, handgrip, and a mental arithmetic stressor. This was followed by a 2-dimensional guided M-mode echocardiographic evaluation to measure LV mass. LV mass was greater among African-Americans relative to Caucasians (p <0.01). Systolic BP at rest was positively associated with LV mass and RWT in African-Americans (p <0.001) and in Caucasian women (p <0.0001). LV mass and RWT were compared in participants and participants were classified as high or low reactors based on their systolic BP responses to the 2 laboratory stressors. RWT demonstrated positive associations with systolic BP responses to both tasks. Associations with LV mass were mostly nonsignificant with the exception of a negative association in African-Americans between systolic BP responses to the arithmetic task and LV mass. We conclude that in this cohort of hypertensive middle-aged men and women, BP reactivity did not predict LV mass. Positive associations of systolic BP responses with RWT suggest that exaggerated reactivity may particularly be related to LV changes influenced by vascular tonus.