Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study
Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study
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DOI：
10.1016/s1053-8119(03)00102-2
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发表时间：
2003-08-01
期刊：
影响因子：
5.7
通讯作者：
Sullivan, EV
中科院分区：
文献类型：
--
作者：
Desmond, JE;Chen, SHA;Sullivan, EV
尽管神经影像、神经病理学和神经心理学研究有明确的证据表明酒精中毒对额叶和小脑的损害，但与酒精者言语工作记忆缺陷有关的小脑和脑小脑回路的功能作用尚未得到很好的研究。酗酒和不酗酒的受试者在接受3T磁铁功能磁共振扫描的同时，进行了斯特恩伯格语言工作记忆任务。这项任务在以前的研究中已经发现，在年轻的健康对照组中，可靠地激活语音环路(左侧额叶、左侧颞叶/顶叶结构、右侧小脑上部区域)的发音控制和语音存储组件。我们假设酗酒者会表现出与对照组不同的激活模式，这是基于先前对健康受试者进行的一项研究确定的感兴趣区(ROI)。行为学结果显示，在准确性和中位反应时间方面，酗酒者的表现与匹配的对照组相当，没有统计学上的显著差异。然而，对功能数据的分析显示，与对照组相比，酗酒者在左侧额叶(BA44/45)和右侧小脑上(HVI)区域表现出更大的激活。这些发现表明，支持言语工作记忆发音控制系统的左侧、额叶和右侧小脑区域的大脑激活可能需要酗酒者补偿性增加，才能保持与对照组相同的表现水平。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
Although there is clear evidence of alcoholism-related damage to the frontal lobes and cerebellum from neuroimaging, neuropathological, and neuropsychological studies, the functional role of the cerebellum and cerebrocerebellar circuits related to verbal working memory deficits of alcoholics have not been well studied. Alcoholic and nonalcoholic subjects performed a Sternberg verbal working memory task while receiving an fMRI scan in a 3T magnet. This task has been found in previous studies to reliably activate the articulatory control and phonological storage components of the phonological loop (left frontal, left temporal/parietal structures, right superior cerebellar regions) in young healthy controls. We hypothesized that the alcoholics would show a different pattern of activation from the controls, based on the regions of interest (ROIs) identified from a previous study of healthy subjects. Behavioral results showed the alcoholics to be performing at a comparable level to the matched controls in terms of accuracy and median reaction time, with no statistically significant differences. However, analysis of the functional data revealed that the alcoholics exhibited greater activation in the left frontal (BA44/45) and right superior cerebellum (HVI) regions relative to the matched controls. These findings suggest that brain activation in left frontal and right cerebellar regions that support the articulatory control system of verbal working memory may require a compensatory increase in alcoholics in order to maintain the same level of performance as controls. (C) 2003 Elsevier Science (USA). All rights reserved.