Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis.
Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis.
复制标题
呼吸道合胞病毒特异性 IgE 反应对细支气管炎后复发性喘息的预测价值。
DOI：
10.1016/s0022-3476(86)80692-8
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Ogra,PL
中科院分区：
文献类型：
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作者：
Welliver,RC;Sun,M;Rinaldo,D;Ogra,PL
为了确定婴儿期呼吸道合胞病毒（RSV）毛细支气管炎发作时RSV特异性IgE反应的幅度是否能准确预测随后喘息发作的发生，我们前瞻性观察了38名婴儿从婴儿毛细支气管炎发作时到48个月大。在毛细支气管炎发作时使用ELISA程序测量峰值RSV-IgE滴度。记录父母报告的随后喘息发作次数和医生记录的次数。在毛细支气管炎发作时未出现RSV-IgE应答的婴儿中，有20%的婴儿和应答最高的婴儿中，有70%的婴儿出现了随后的喘息（P<0.025）。这些结果表明，RSV毛细支气管炎时RSV-IgE反应的幅度是一个有用的复发性喘息的预后指标。
To determine whether the magnitude of the respiratory syncytial virus (RSV)-specific IgE response at the time of an episode of RSV bronchiolitis in infancy accurately predicts the development of subsequent wheezing episodes, we observed 38 infants prospectively from the time of an episode of infantile bronchiolitis through 48 months of age. Peak RSV-IgE titers were measured at the time of the bronchiolitis episode using an ELISA procedure. Notation was made of both the number of subsequent wheezing episodes reported by parents and the number documented by a physician. Subsequent wheezing was documented by a physician in 20% of infants who did not develop an RSV-IgE response at the time of the bronchiolitis episode and in 70% of those with the highest responses (P<0.025). These results suggest that the magnitude of the RSV-IgE response at the time of RSV bronchiolitis is a useful prognostic indicator for recurrent wheezing.