The Emerging Roles of Long Noncoding RNAs in Bone Homeostasis and Their Potential Application in Bone-Related Diseases
The Emerging Roles of Long Noncoding RNAs in Bone Homeostasis and Their Potential Application in Bone-Related Diseases
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长链非编码 RNA 在骨稳态中的新作用及其在骨相关疾病中的潜在应用
DOI：
10.1089/dna.2020.5391
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发表时间：
2020-04-29
影响因子：
3.1
通讯作者：
Xiao, Yu
中科院分区：
文献类型：
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作者：
Song, Wei;Xie, Jiahui;Xiao, Yu
越来越多的证据表明，长链非编码 RNA (lncRNA) 由于其对骨相关细胞的增殖、迁移、分化和凋亡的潜在调节作用，在调节骨稳态中发挥着新的作用。因此，lncRNA被认为是一种有前途的基因工具，可以促进骨再生过程，进而预测和治疗骨相关疾病，如骨肉瘤、骨质疏松症和骨关节炎。在这篇综述中，我们首先列举了几种失调的lncRNA，并简要总结了它们在骨形成和骨吸收过程中的调节作用。还分别讨论了相关机制。然后，阐明了这些 lncRNA 在骨相关疾病中的积极或消极行为。该综述深入探讨了lncRNA的临床价值和局限性，有利于探索新的基因靶点，进一步建立骨相关疾病的新治疗策略。
Increasing evidence has announced the emerging roles of long noncoding RNAs (lncRNAs) in modulating bone homeostasis due to their potential regulating effects on bone-related cells' proliferation, migration, differentiation and apoptosis. Thus, lncRNAs have been considered as a promising gene tool to facilitate the bone regeneration process and then to predict and cure bone-related diseases such as osteosarcoma, osteoporosis, and osteoarthritis. In this review, we first enumerated several kinds of dysregulated lncRNAs and concisely summarized their regulating role in bone formation as well as resorption process. The related mechanisms were also discussed, respectively. Then, the positive or negative behavior of these lncRNAs in bone-related diseases was elucidated. This review provides an in-depth sight about the lncRNA's clinical values and limitations, which is conducive to explore new gene targets and further establish new therapeutic strategies for bone-related disease.