Alternative mitophagy is a major form of mitophagy in the chronically stressed heart.
Alternative mitophagy is a major form of mitophagy in the chronically stressed heart.
复制标题
替代性线粒体自噬是长期应激心脏中线粒体自噬的主要形式。
DOI：
10.1080/15548627.2022.2025573
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发表时间：
2022
期刊：
影响因子：
13.3
通讯作者：
Sadoshima,Junichi
中科院分区：
文献类型：
--
作者：
Sadoshima,Junichi
线粒体功能障碍是肥胖和糖尿病患者发生心肌病的关键决定因素。我们最近报道，在高脂饮食(HFD)消费的慢性阶段，小鼠心脏中的有丝分裂吞噬被激活，尽管一般的宏观自噬/自噬下调。这种形式的有丝分裂吞噬是由一种不同于传统自噬的机制介导的，被称为替代有丝分裂吞噬。我们在这里讨论替代有丝分裂吞噬的潜在机制及其在心脏病中的功能意义。
Mitochondrial dysfunction is a key determinant of the development of cardiomyopathy in patients with obesity and diabetes. We recently reported that mitophagy is activated in the mouse heart during the chronic phase of high-fat diet (HFD) consumption, despite downregulation of general macroautophagy/autophagy. This form of mitophagy is mediated by a mechanism distinct from that of conventional autophagy and is termed alternative mitophagy. We here discuss the underlying mechanisms of alternative mitophagy and its functional significance in heart disease.