MicroRNAs and Circular RNAs in Lipoprotein Metabolism.
MicroRNAs and Circular RNAs in Lipoprotein Metabolism.
复制标题
脂蛋白代谢中的microRNAs和Circular RNAs。
DOI：
10.1007/s11883-021-00934-3
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发表时间：
2021-05-10
影响因子：
5.8
通讯作者：
Fernandez-Hernando, Carlos
中科院分区：
文献类型：
--
作者：
Fernandez-Tussy, Pablo;Ruz-Maldonado, Inmaculada;Fernandez-Hernando, Carlos
非编码RNA（ncRNA）包括microRNA（miRNAs）和circular RNA（circRNAs），是mRNA和蛋白质表达的关键调节因子，其对心血管病理生理学起关键作用。虽然对这些ncRNA的起源和功能知之甚少，但它们已被认为是有前途的生物标志物，在心血管疾病（CVD）中具有强大的治疗价值。在这篇综述中，我们总结了ncRNAs生物学的最新发现及其对胆固醇稳态和脂蛋白代谢的影响，突出了治疗血脂异常和动脉粥样硬化的新的治疗途径。临床和实验研究已经阐明了特异性miRNA直接和间接调节循环高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）代谢和心血管风险的潜在作用。这些相关miRNA中的一些包括miR-148 a、miR-128-1、miR-483、miR-520 d、miR-224、miR-30 c、miR-122、miR-33、miR-144和miR-34。已知circRNA由于其在组织中的丰度和其阶段特异性表达激活而参与多种生理和病理过程。最近的研究已经证明，circRNA也可以被认为是CVD的靶点。这些cirRNA中的一些是circ-0092317、circ_0003546、circ_0028198和cirFmRNA，它们被认为强烈参与脂蛋白代谢，然而它们在CVD中的相关性仍然未知。microRNA和cirRNA已被提出作为治疗包括动脉粥样硬化在内的心脏代谢疾病的强大治疗靶标。在这里，我们讨论了脂质和脂蛋白代谢领域的最新研究结果，强调了其中一些ncRNA影响脂蛋白代谢和CVD的新机制。
Non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and circular RNAs (circRNAs) are pivotal regulators of mRNA and protein expression that critically contribute to cardiovascular pathophysiology. Although little is known about the origin and function of such ncRNAs, they have been suggested as promising biomarkers with powerful therapeutic value in cardiovascular disease (CVD). In this review, we summarize the most recent findings on ncRNAs biology and their implication on cholesterol homeostasis and lipoprotein metabolism that highlight novel therapeutic avenues for treating dyslipidemia and atherosclerosis. Clinical and experimental studies have elucidated the underlying effects that specific miRNAs impose both directly and indirectly regulating circulating high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very-low density lipoprotein (VLDL) metabolism and cardiovascular risk. Some of these relevant miRNAs include miR-148a, miR-128-1, miR-483, miR-520d, miR-224 miR30c, miR-122, miR-33, miR-144 and miR-34. circRNAs are known to participate in a variety of physiological and pathological processes due to their abundance in tissues and their stage-specific expression activation. Recent studies have proven that circRNAs may be considered targets of CVD as well. Some of these cirRNAs are circ-0092317, circ_0003546, circ_0028198 and cirFASN that have been suggested to be strongly involved in lipoprotein metabolism however their relevance in CVD is still unknown. MicroRNA and cirRNAs have been proposed as powerful therapeutic targets for treating cardiometabolic disorders including atherosclerosis. Here, we discuss the recent findings in the field of lipid and lipoprotein metabolism underscoring the novel mechanisms by which some of these ncRNAs influences lipoprotein metabolism and CVD.
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影响因子：
29
作者：
Fernández-Hernando C;Yu J;Suárez Y;Rahner C;Dávalos A;Lasunción MA;Sessa WC
通讯作者：
Sessa WC
影响因子：
12.4
作者：
通讯作者：
--
影响因子：
30.8
作者：
Bodzioch, M;Orsó, E;Schmitz, G
通讯作者：
Schmitz, G
影响因子：
3.7
作者：
Gore, M. Odette;McGuire, Darren K.;Rosenstock, Julio
通讯作者：
Rosenstock, Julio
影响因子：
4.4
作者：
Aryal B;Singh AK;Rotllan N;Price N;Fernández-Hernando C
通讯作者：
Fernández-Hernando C