Pathogenesis and treatment of human genital papillomavirus infections: a review.
Pathogenesis and treatment of human genital papillomavirus infections: a review.
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人类生殖器乳头瘤病毒感染的发病机制和治疗：综述。
DOI：
10.1016/0166-3542(89)90022-3
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发表时间：
1989
影响因子：
7.6
通讯作者：
Strike,DG
中科院分区：
文献类型：
--
作者：
Reichman,RC;Strike,DG
生殖道HPV感染是常见的，肛门生殖器疣或尖锐湿疣的发病率正在迅速增加。此外，某些HPV类型与生殖道恶性肿瘤密切相关。尽管分子生物学的最新进展使人们对乳头瘤病毒基因组的组织和功能有了更多的了解，但HPV感染的发病机制和宿主对这些疾病的反应仍然知之甚少。治疗肛门生殖器疣是困难的，目前没有完全满意的治疗方式。相对较少的治疗方式已被彻底评估，虽然最近的研究，病灶内和肠道外给药的干扰素已证明干扰素的有益效果相比，安慰剂。需要对尖锐湿疣的治疗进行进一步的研究，应包括使用生物反应调节剂，如干扰素，以及抗病毒药物，有或没有常规的局部治疗方法。
HPV infection of the genital tract is common and anogenital warts or condyloma acuminatum is increasing rapidly in incidence. In addition, certain HPV types are closely associated with genital tract malignancies. Although recent advances in molecular biology have led to an increased understanding of the organization and functions of the papillomavirus genome, the pathogenesis of HPV infections and host responses to these diseases remain poorly understood. Treatment of anogenital warts is difficult and no completely satisfactory treatment modality is currently available. Comparatively few therapeutic modalities have been thoroughly evaluated, although recent studies of intralesionally and parenterally administered interferons have demonstrated beneficial effects of interferon compared to placebo. Additional studies of treatment for condyloma acuminatum are needed and should include the use of biologic response modifiers such as interferons, as well as antiviral drugs, with or without conventional methods of local therapy.