Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
复制标题
DOI：
10.1063/1.3699063
复制
发表时间：
2012-03-01
期刊：
影响因子：
1.6
通讯作者：
Borghesi, M.
中科院分区：
文献类型：
--
作者：
Doria, D.;Kakolee, K. F.;Borghesi, M.
激光驱动的多兆电子伏特离子爆发的超短持续时间为极高剂量率的放射生物学研究提供了可能性。利用女王大学的TARANIS太瓦激光器，在mev范围内能量的质子照射对活细胞的影响进行了研究，剂量率超过10(9)Gy/s作为单次照射。一项克隆性试验显示，即使在这些剂量率下，对V-79活细胞的致命影响也一致，这似乎与以前发表的使用传统来源的结果一致。通过与225 kVp x射线源的比较，估计在10%存活率下的相对生物有效性（RBE）为1.4 +/- 0.2。版权所有2012作者本文采用知识共享署名3.0未移植许可协议发布。[http://dx.doi.org/10.1063/1.3699063]
The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10(9) Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4 +/- 0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. Copyright 2012 Author(s). This article is distributed under a Creative Commons Attribution 3.0 Unported License. [http://dx.doi.org/10.1063/1.3699063]