Understanding Bland Altman analysis.
Understanding Bland Altman analysis.
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DOI：
10.11613/bm.2015.015
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发表时间：
2015
期刊：
影响因子：
3.3
通讯作者：
Giavarina D
中科院分区：
文献类型：
--
作者：
Giavarina D
在当代临床实验室中，必须评估两种定量测量方法之间的一致性是非常常见的。评估这种一致程度的正确统计方法并不明显。相关性和回归研究经常被提出。然而，相关性研究一个变量与另一个变量之间的关系，而不是差异，并且不推荐将其作为评估方法之间可比性的方法。
1983年，Altman和Bland（B&A）提出了一种替代分析，其基于通过研究平均差异和构建一致性限度来量化两个定量测量之间的一致性
。B& A图分析是一种简单的方法，用于评估平均差异之间的偏倚，并估计一致区间，与第一种方法相比，第二种方法的95%差异都落在该区间内。数据可以用单位差异图和百分比差异图来分析。B&A图方法只定义了一致性的区间，它没有说这些区间是否可以接受。
可接受的限度必须事先定义，根据临床需要，生物学考虑或其他目标。本文的目的是提供指导的使用和解释的Bland Altman分析方法比较研究。
In a contemporary clinical laboratory it is very common to have to assess the agreement between two quantitative methods of measurement. The correct statistical approach to assess this degree of agreement is not obvious. Correlation and regression studies are frequently proposed. However, correlation studies the relationship between one variable and another, not the differences, and it is not recommended as a method for assessing the comparability between methods.
In 1983 Altman and Bland (B&A) proposed an alternative analysis, based on the quantification of the agreement between two quantitative measurements by studying the mean difference and constructing limits of agreement.
The B&A plot analysis is a simple way to evaluate a bias between the mean differences, and to estimate an agreement interval, within which 95% of the differences of the second method, compared to the first one, fall. Data can be analyzed both as unit differences plot and as percentage differences plot.
The B&A plot method only defines the intervals of agreements, it does not say whether those limits are acceptable or not. Acceptable limits must be defined a priori, based on clinical necessity, biological considerations or other goals.
The aim of this article is to provide guidance on the use and interpretation of Bland Altman analysis in method comparison studies.