Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14
Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14
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DOI：
10.1006/geno.1996.0377
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发表时间：
1996-07-15
期刊：
影响因子：
4.4
通讯作者：
Casey, G
中科院分区：
文献类型：
--
作者：
Xu, Y;Casey, G
我们描述了从映射到染色体 14q31 的卵巢癌细胞系中克隆出一种新型 G 蛋白偶联受体，称为卵巢癌 G 蛋白偶联受体 1 (OGR1)。预测的OGR1开放阅读框编码365个氨基酸的蛋白质。 OGR1 在多种组织中以单个 3.0-kb 转录物的形式表达，包括脾、睾丸、小肠、外周血白细胞、脑、心脏、肺、胎盘和肾，而在胸腺、前列腺、卵巢、结肠、肝脏、骨骼肌或胰腺中未检测到 OGR1 表达。 OGR1 与人类孤儿受体 GPR4 具有最强的同源性 (49-54%)。 OGR1的结构特征表明OGR1的配体很可能是小肽或小生物活性分子。 (C) 1996 学术出版社
We describe the cloning of a novel G protein-coupled receptor, termed ovarian cancer G protein-coupled receptor 1 (OGR1), from an ovarian cancer cell line that maps to chromosome 14q31. The predicted open reading frame of OGR1 encodes a protein of 365 amino acids. OGR1 is expressed as a single 3.0-kb transcript in several tissues, including spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta, and kidney, with no detectable OGR1 expression in thymus, prostate, ovary, colon, liver, skeletal muscle, or pancreas. OGR1 shares strongest homology (49-54%) with the human orphan receptor GPR4. The structural features of OGR1 suggest that the ligand for OGR1 is likely to be a small peptide or a small bioactive molecule. (C) 1996 Academic Press, Inc.