Defining the Occurrence and Influence of Alpha-Delta Sleep in Chronic Fatigue Syndrome
Defining the Occurrence and Influence of Alpha-Delta Sleep in Chronic Fatigue Syndrome
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定义阿尔法-德尔塔睡眠对慢性疲劳综合症的发生和影响
DOI：
10.1097/00000441-200702000-00003
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
K. D. De Meirleir
中科院分区：
文献类型：
--
作者：
E. Van Hoof;P. De Becker;C. Lapp;R. Cluydts;K. D. De Meirleir
背景：慢性疲劳综合征（CFS）患者表现为睡眠模式紊乱，经常接受多导睡眠图检查以排除原发性睡眠障碍。这些研究已经显示了睡眠效率降低，深度睡眠减少，睡眠开始时间延长，以及深度睡眠期间的α波侵入。2-5A合成酶/RNase L抗病毒途径的失调和潜在的获得性通道病也在CFS患者的一个子集中发现，并可能导致睡眠障碍。本文汇编了一个关于CFS患者的大型睡眠研究数据库，并将这些数据与有限数量的免疫参数相关联，因为人们认为RNase L可能与这些睡眠障碍有关。方法：48例符合1994年疾病控制和预防中心CFS标准的患者接受了广泛的医学评估，常规实验室检查和结构化精神病学访谈。然后，受试者完成了一个投诉清单和两个晚上的多导睡眠图调查。使用放射性标记的2′，5 ′-寡腺苷酸三聚体通过凝胶电泳进行RNase L分析。计算基本描述性统计参数。结果：患者睡眠潜伏期延长，睡眠效率指数低，慢波睡眠比例低。目前的α-δ侵入与焦虑相关;然而，α-δ睡眠与免疫学参数（包括RNA酶L）之间没有相关性。结论：主要发现是1）睡眠潜伏期问题和其他睡眠障碍的验证，正如几位作者已经提出的那样; 2）α-δ侵入似乎与焦虑有关; 3）RNase L升高与α-δ睡眠无关。
Background:Patients with chronic fatigue syndrome (CFS) present a disordered sleep pattern and frequently undergo polysomnography to exclude a primary sleep disorder. Such studies have shown reduced sleep efficiency, a reduction of deep sleep, prolonged sleep initiation, and alpha-wave intrusion during deep sleep. Deregulation of the 2-5A synthetase/RNase L antiviral pathway and a potential acquired channelopathy are also found in a subset of CFS patients and could lead to sleep disturbances. This article compiles a large sleep study database on CFS patients and correlates these data with a limited number of immune parameters as it has been thought that RNase L could be associated with these sleep disturbances. Methods:Forty-eight patients who fulfilled 1994 Centers for Disease Control and Prevention criteria for CFS underwent extensive medical evaluation, routine laboratory testing, and a structured psychiatric interview. Subjects then completed a complaint checklist and a two-night polysomnographic investigation. RNase L analysis was performed by gel electrophoresis using a radiolabeled 2′,5′-oligoadenylate trimer. Basic descriptive statistical parameters were calculated. Results:Patients experienced a prolonged sleep latency, showed a low sleep efficiency index, and had a low percentage of slow wave sleep. The present alpha-delta intrusion correlated with anxiety; no correlations appeared, however, between alpha-delta sleep and immunologic parameters, including RNase L. Conclusions:The main findings are 1) validation of sleep latency problems and other sleep disturbances as already suggested by several authors; 2) alpha-delta intrusion seems associated with anxiety; and 3) elevated RNase L did not correlate with alpha-delta sleep.
慢性疲劳患者的睡眠障碍。
DOI：
10.1093/clinids/18.supplement_1.s68
发表时间：
1994
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Buchwald,D;Pascualy,R;Bombardier,C;Kith,P
通讯作者：
Kith,P
慢性疲劳综合症的症状和体征。
DOI：
10.1093/clinids/13.supplement_1.s8
发表时间：
1991
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Komaroff,AL;Buchwald,D
通讯作者：
Buchwald,D