CD4+CD25+FoxP3+ regulatory T cells are increased whilst CD3+CD4-CD8-αβTCR+ Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
CD4+CD25+FoxP3+ regulatory T cells are increased whilst CD3+CD4-CD8-αβTCR+ Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
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DOI：
10.1111/j.1365-2141.2008.07530.x
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发表时间：
2009-03-01
影响因子：
6.5
通讯作者：
Cook, Gordon
中科院分区：
文献类型：
--
作者：
Feyler, Sylvia;von Lilienfeld-Toal, Marie;Cook, Gordon
在各种实体瘤和血液恶性肿瘤中发现了天然存在的调节性T细胞（T-Reg细胞）水平的增加。在多发性骨髓瘤（MM）中，有证据表明T-Reg细胞增加，尽管其功能存在争议，但与疾病分期和治疗无关。在此，我们证明了与年龄匹配的健康对照组相比，在一个大型MM患者队列以及意义不明的单克隆丙种球蛋白病（MGUS）患者中，功能性CD 4（+）CD 25（+）FoxP 3（+）T-Reg细胞水平显著升高。还评价了双阴性T-Reg细胞的频率，表明MM患者中这些细胞减少。此外，与健康对照相比，MM和MGUS患者外周血和骨髓中免疫调节细胞因子的特征性谱得到证实。这些数据为理解T-Reg细胞亚群在肿瘤免疫学中的作用以及宿主/肿瘤免疫冲突的基本原理提供了进一步的证据。
Increased levels of naturally occurring regulatory T cells (T-Reg cells) have been found in a variety of solid tumours and haematological malignancies. In multiple myeloma (MM), evidence suggests that T-Reg cells are increased though controversy exists with regards to their function and no relationship to disease stage and treatment has been demonstrated. Here, we demonstrate significantly elevated levels of functional CD4(+)CD25(+)FoxP3(+) T-Reg cells in a large cohort of patients with MM as well as monoclonal gammopathy of uncertain significance (MGUS) in comparison to age-matched, healthy controls. The frequency of Double Negative T-Reg cells was also evaluated, demonstrating that these cells were reduced in patients with MM. Furthermore, a characteristic profile of immunomodulatory cytokines in the peripheral blood and bone marrow of patients with MM and MGUS was demonstrated, compared with healthy controls. This data adds further evidence to the understanding of the role of T-Reg cell subsets in tumour immunology and the fundamentals of the host/tumour immune conflict.