Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism.
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism.
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DOI：
10.3390/biology4010104
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发表时间：
2015-02-05
期刊：
影响因子：
4.2
通讯作者：
Parini P
中科院分区：
文献类型：
--
作者：
Gnocchi D;Pedrelli M;Hurt-Camejo E;Parini P
脂质和脂蛋白代谢和转运的障碍是导致从心血管疾病到代谢综合征，甚至到肿瘤发展的多种病理的原因。最近，对控制我们生物钟和昼夜节律的分子机制有了更深入的了解。从这些研究中，我们清楚地发现了分子钟是如何紧密地调节我们生活的各个方面的，包括我们的新陈代谢。这篇综述分析了生物钟的组织和功能及其在生理过程调节中的相关性。我们还将脂质和脂蛋白的代谢和运输描述为我们健康的一个重要方面，我们将专注于生物钟和脂质代谢是如何相互联系的。最后，我们讨论了如何更深入地了解这种关系可能是有用的，以改善最近的代谢疾病的传播。
Disorders of lipid and lipoprotein metabolism and transport are responsible for the development of a large spectrum of pathologies, ranging from cardiovascular diseases, to metabolic syndrome, even to tumour development. Recently, a deeper knowledge of the molecular mechanisms that control our biological clock and circadian rhythms has been achieved. From these studies it has clearly emerged how the molecular clock tightly regulates every aspect of our lives, including our metabolism. This review analyses the organisation and functioning of the circadian clock and its relevance in the regulation of physiological processes. We also describe metabolism and transport of lipids and lipoproteins as an essential aspect for our health, and we will focus on how the circadian clock and lipid metabolism are greatly interconnected. Finally, we discuss how a deeper knowledge of this relationship might be useful to improve the recent spread of metabolic diseases.