Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible?
Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible?
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DOI：
10.1016/s0022-3956(97)00038-1
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发表时间：
1998-05-01
影响因子：
4.8
通讯作者：
Pettegrew, JW
中科院分区：
文献类型：
--
作者：
Keshavan, MS;Haas, GL;Pettegrew, JW
越来越多的证据表明，精神分裂症患者的大脑结构发生了变化，尤其是前额叶和颞叶皮层。先前对精神分裂症大脑结构改变进展的研究得出了相互矛盾的结果。对一系列未使用抗精神病药的首发精神分裂症患者、非精神分裂症首发精神病患者以及匹配的健康对照者进行了颞上回（STG）体积的形态测量研究。在这些受试者治疗一年之前和之后进行了三维 MRI 扫描。两组患者的左颞上回基线时体积均减少（根据颅内体积进行调整）。治疗前的病程与左颞上回的体积呈负相关；这种关系仅限于男性。对一小部分患者进行的一年随访 MRI 研究表明，STG 体积减少可能是可逆的。在基线和一年随访时也进行扫描的匹配健康对照中，STG 体积没有发现显着变化。这些发现对于理解早期精神分裂症神经病理过程的本质以及早期治疗的潜在影响具有重要意义。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
Accumulating evidence suggests alterations in brain structure, especially in the prefrontal and temporal cortex, in schizophrenia. Previous studies examining the progression of brain structural alterations in schizophrenia have led to conflicting results. Morphometric studies of the superior temporal gyrus (STG) volumes were conducted in a series;of neuroleptic-naive first-episode schizophrenic patients, non-schizophrenic first-episode psychotic patients, and matched healthy controls. Three-dimensional MRI scans were carried out in these subjects before and after one year of treatment. Volume reductions were seen at baseline in the left superior temporal gyrus (adjusted for intracranial volume) in both of the patient groups. Pretreatment illness duration was inversely related to the volume of the left superior temporal gyrus; this relation was confined to males. One-year follow-up MRI investigations in a smaller subset of patients suggested that the STG volume reductions may be reversible. No significant changes were noted in the STG volumes in matched healthy controls who were also scanned at baseline as well as at one-year follow-up. These findings have implications for understanding the nature of the neuropathological processes in early schizophrenia, as well as the potential impact of early treatment. (C) 1998 Elsevier Science Ltd. All rights reserved.