A congenital medulloepithelioma of the midbrain
A congenital medulloepithelioma of the midbrain
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先天性中脑髓质上皮瘤
DOI：
10.1002/path.1700740214
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发表时间：
1957
期刊：
影响因子：
--
通讯作者：
C. Treip
中科院分区：
文献类型：
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作者：
C. Treip
在 Bailey 和 Cushing (1926) 提出的神经胶质瘤的组织遗传学分类中，该系列中最原始的肿瘤被认为起源于髓质板的上皮，被描述为髓质上皮瘤。贝利和库欣在他们的系列中只发现了两个肿瘤，他们可以将其归入此标题。一个起源于第三脑室的漏斗部后区域，另一个起源于松果体部位，其中以内界膜为特征的髓板细胞持续到出生后的生命中（Benda，1898）。两种肿瘤均由或多或少分化的柱状细胞小管组成，部分分层并具有内部和外部限制膜。其中一个肿瘤显示出一些血管周围玫瑰花结的形成。在这两种情况下，细胞都不含有纤毛或眼睑，尽管在第二种情况下（第 54 页），许多细胞中都存在双倍体。自从第一次描述和命名肿瘤以来，很少有进一步的例子被报道（Davie，1932；Greenfield，1934），并且它的存在已受到质疑（Mabon 等人，1950）。原始髓质上皮在胚胎生命第五周末开始发育纤毛。 Russell (1950) 指出，纤毛持续到成年，而纤毛室管膜细胞实际上是成熟的形式；它是没有纤毛的原始细胞。纤毛发育的早期阶段可以解释真正的髓质上皮的极其罕见。
IN the histogenetic classification of the gliomas proposed by Bailey and Cushing (1926) the most primitive tumour of the series, postulated as arising from the epithelium of the medullary plate, was described as medulloepithelioma. Bailey and Cushing were able to find only two tumours in their series which they could put under this heading. One arose from the post-infundibular region of the third ventricle, the other from the pineal-sites in which medullary-plate cells, characterised by an internal limiting membrane, persist into post-natal life (Benda, 1898). Both tumours consisted of more or less differentiated tubules of columnar cells, partly stratified and possessing internal and external limiting membranes. One of the tumours showed some formation of perivascular rosettes. In neither did the cells contain cilia or blepharoplasts, though in the second case (p. 54) a diplosome was present in many cells.Since this first description and naming of the tumour very few further examples have been reported (Davie, 1932; Greenfield, 1934) and its existence has been called into question (Mabon et aZ., 1950). The primitive medullary epithelium begins to develop cilia at the end of the fifth week of embryonic life. Russell (1950) has pointed out that cilia persist into adult life and that the ciliated ependymal cell is in fact the mature form; it is the primitive cell that is free of cilia. The very early stage at which cilia develop would explain the extreme rarity with which true medullary epithelium has been found.