Overexpression of P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma
Overexpression of P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma
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P4HB 过度表达与人透明细胞肾细胞癌的不良预后相关
DOI：
10.3233/cbm-190450
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发表时间：
2019-01-01
影响因子：
3.1
通讯作者：
Lin, Jian
中科院分区：
文献类型：
--
作者：
Zhu, Zhenpeng;He, Anbang;Lin, Jian
脯氨酰4-羟化酶β多肽（P4 HB）蛋白与多种肿瘤的发生有关，但P4 HB与肾透明细胞癌（ccRCC）的关系尚不清楚。本研究旨在探讨P4 HB的表达与肾细胞癌的关系。通过癌症基因组图谱（TCGA）数据库，基因表达综合数据库（GEO），我们的数据库和免疫组织化学（IHC）染色。与癌旁正常组织相比，ccRCC组织中P4 HB的mRNA和蛋白水平均明显升高。Kaplan-Meier生存分析显示，在TCGA数据库和我们自己的数据库中，P4 HB高表达与不良预后相关。多因素生存分析和单因素生存分析显示，P4 HB表达和年龄与预后不良显著相关。提示P4 HB与肾透明细胞癌预后不良有关。
Prolyl 4-hydroxylase, beta polypeptide (P4HB) protein has been found to be associated with tumorigenesis in many types of tumor, However, the relationship between P4HB and clear cell renal cell carcinoma (ccRCC) has not been clarified. In this study, we focus on the correlation between P4HB expression and ccRCC. Through the Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, our database and immunohistochemical (IHC) staining. Compared with adjacent normal tissues, both the mRNA and protein levels of P4HB in ccRCC tissues were enhanced. The Kaplan-Meier survival analysis showed that high expression of P4HB is correlated with poor prognosis in both TCGA database and our own database. Multivariate survival analysis and Univariate analysis showed that P4HB expression and age are significantly correlative with poor prognose. All the results indicated that P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma.