BLINDNESS CAUSED BY PHOTORECEPTOR DEGENERATION AS A REMOTE EFFECT OF CANCER
BLINDNESS CAUSED BY PHOTORECEPTOR DEGENERATION AS A REMOTE EFFECT OF CANCER
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DOI：
10.1016/0002-9394(76)90125-2
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发表时间：
1976-01-01
影响因子：
4.2
通讯作者：
HOYT, WF
中科院分区：
文献类型：
--
作者：
SAWYER, RA;SELHORST, JB;HOYT, WF
三名绝经后妇女在发现间变性肿瘤之前或之后一到四个月发生了光感受器退化。两名患者有短暂的视觉模糊和奇怪的视觉感觉。环状暗点进展为严重的视野丧失。视网膜动脉明显狭窄。视网膜电描记图显示一名患者几乎完全没有反应，另一名患者抱怨最近出现了夜盲。在所有三例患者中，组织学显示与嗜黑素活动相关的感光细胞严重变性。在两名患者中，从视网膜双极细胞到枕叶皮质的神经病理检查显示没有明显变化。
Three postmenopausal women developed photoreceptor degeneration one to four months preceding or following discovery of an anaplastic tumor. Two patients had transitory visual obscurations and bizarre visual sensations. Ring scotomas progressed to severe visual field loss. Retinal arteries were markedly narrowed. Electroretinograms revealed almost total absence of response in one patient, and another complained of the recent onset of night blindness. In all three patients severe degeneration of the photoreceptor cells associated with melanophagic activity was shown histologically. In two patients neuropathologic examination from the retinal bipolar cells to the occipital cortex revealed no significant alterations.