Effects of 5-halogenated uracils on the growth of Escherichia coli and their incorporation into deoxyribonucleic acids.
Effects of 5-halogenated uracils on the growth of Escherichia coli and their incorporation into deoxyribonucleic acids.
复制标题
5-卤代尿嘧啶对大肠杆菌生长及其掺入脱氧核糖核酸的影响。
作者：
D. B. Dunn;J. Smith
已知嘌呤和嘧啶的多种结构类似物影响病毒、细菌和其他微生物、植物和动物的生长。其中一些可以通过掺入核酸中代替天然嘌呤或嘧啶来发挥作用。这些例子是：8-氮鸟嘌呤，鸟嘌呤的结构类似物，已被证明可取代烟草花叶病毒核糖核酸（RNA）中的鸟嘌呤（马修斯，1953），并被掺入芜菁黄花叶病毒的RNA中（马修斯，1955），几种微生物（Henrich，Dewey，Parks & Kidder，1952; Lasnitzki，马修斯& Smith，1954;马修斯& Smith，1956），小鼠肿瘤和正常组织（Mitchell，Skipper &班尼特，1950; Mandel，Carlo & Smith，1954; Lasnitzki et al.1954），以及掺入烟草花叶病毒核酸中的2-硫尿嘧啶（Jeener & Rosseels，1953;马修斯，1956）。
A variety of structural analogues of purines and pyrimidines are known to affect the growth of viruses, bacteria and other micro-organisms, plants and animals. Some of these may exert their action through being incorporated into nucleic acids in place of the natural purine or pyrimidine. Such examples are: 8-azaguanine, a structural analogue of guanine, which has been shown to replace guanine in the ribonucleic acid (RNA) of tobaccomosaic virus (Matthews, 1953), and is incorporated into the RNA of turnip-yellow-mosaic virus (Matthews, 1955), of several micro-organisms (Henrich, Dewey, Parks & Kidder, 1952; Lasnitzki, Matthews & Smith, 1954; Matthews & Smith, 1956), of both mouse tumour and normal tissues (Mitchell, Skipper & Bennett, 1950; Mandel, Carlo & Smith, 1954; Lasnitzki et al. 1954), and 2thiouracil which is incorporated into the nucleic acid of tobacco-mosaic virus (Jeener & Rosseels, 1953; Matthews, 1956).