Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire
Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire
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DOI：
10.1186/s12968-015-0189-y
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发表时间：
2015-10-02
影响因子：
6.4
通讯作者：
Firmin, David N.
中科院分区：
文献类型：
--
作者：
Keegan, Jennifer;Raphael, Claire E.;Firmin, David N.
背景资料：冠状动脉血流速度的时间模式可以提供关于疾病状态的重要信息，并且目前使用多普勒导丝进行侵入性评估。一个非侵入性的替代方案将是有益的，因为它将允许更广泛的患者人群和serial scanning.Methods的研究：回顾性门控屏气螺旋相位速度映射序列（TR 19 ms），开发在3特斯拉。在18名受试者的8支近端右冠状动脉和15支近端左冠状动脉中采集速度图，这些受试者之前在冠状动脉造影时进行了多普勒导丝研究。心血管磁共振（CMR）速度-时间曲线进行半自动处理，并与相应的有创多普勒数据进行比较。当校正两项研究之间的心率差异时，CMR通过心动周期的平均速度，收缩期峰值流速（PSV）和舒张期峰值流速（PEN）约为多普勒峰值的40%，两种方法之间有良好的线性关系（R-2分别为0.57、0.64和0.79）。PDV/PSV的CMR值与多普勒值呈强线性关系，斜率接近1（右动脉和左动脉分别为0.89和0.90）。在个别血管中，所有心脏相位的CMR速度与相应的多普勒速度的曲线显示了两者之间一致的线性关系，具有高R2值（平均值+/-SD：0.79 +/-.13）。结论：高时间分辨率屏气螺旋相位速度映射低估了冠状动脉血流速度的绝对值，但可以准确评估血流的时间模式。
Background: Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.Methods: A retrospectively gated breath hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi automatically and compared with corresponding invasive Doppler data.Results: When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PEN) were approximately 40 % of the peak Doppler values with a moderate - good linear relationship between the two techniques (R-2: 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R2 values (mean +/-SD: 0.79 +/-.13).Conclusions: High temporal resolution breath hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.