DR2 (DRw15, 16): 2-D Gel Patterns
DR2 (DRw15, 16): 2-D Gel Patterns
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DR2 (DRw15, 16)：2-D 凝胶图案
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
W. Marshall
中科院分区：
文献类型：
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作者：
N. Rust;C. Carter;S. Fuggle;S. Sacks;P. Hermans;D. Charron;T. Nakatsuji;Kim Wong;C. Dejelo;W. Marshall
第9次研讨会的结果确定了DR2单倍型中的两个血清学分裂(长和短)。异质性也通过细胞分型来定义；识别和描述了三种形式：DW2(普通高加索人)、DW12(日本变种)和“fjo”(“LD2s”)。结果的比较分析表明，细胞类型“LD2s”被血清识别为DR2 Short(1)。RFLP(2)和2-D Gel(3，4)分析的其他研究描述了进一步的多态性。在本讲习班中，这三个亚型已得到确认并得到世卫组织的认可(5)。DR2 Long现在被称为DRw15，DR2 Short被称为DRw16。DRw16可以与DQw1或DQw3相关联，DQw1或DQw3分别被赋予Dw特性Dw21(LD2)和Dw22(LD5a)。DQw1有两个亚型，即DQw5(DQw1.1)和DQw6(DQw1.2)。这些新的特异性与工作室的2-D凝胶图谱的关联如表1所示。
The results of the 9th Workshop identified two serologic splits within the DR2 haplotype (long and short). Heterogeneity was also defined by cellular typing; three forms were identified and described as Dw2 (common Caucasian), Dw12 (Japanese variant), and “FJO” (“LD2s”). A comparative analysis of the results indicated that the cellular type “LD2s” was recognized by sera as DR2 short (1). Other studies by RFLP(2) and 2-D gel (3,4) analysis described further polymorphism. In this Workshop, these three subtypes have been confirmed and given WHO recognition (5). DR2 long is now called DRw15 and DR2 short is DRw16. DRw16 can be associated with either DQw1 or DQw3, which have been given separate Dw specificities, Dw21 (LD2s) and Dw22 (LD5a), respectively. Two subtypes of DQw1 have been serologically defined, namely, DQw5 (DQw1.1) and DQw6 (DQw1.2). The association of these new specificities with the Workshop 2-D gel patterns is shown in Table 1.