miR-145: Revival of a Dragon in Pancreatic Cancer.
miR-145: Revival of a Dragon in Pancreatic Cancer.
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发表时间：
2017-03
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通讯作者：
Saini Setua;S. Khan;Kyle A Doxtater;M. Yallapu;M. Jaggi;S. Chauhan
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作者：
Saini Setua;S. Khan;Kyle A Doxtater;M. Yallapu;M. Jaggi;S. Chauhan
MicroRNA-145（miR-145）作为胰腺癌中的肿瘤抑制因子的作用的出现为新的治疗干预提供了潜力。我们最近发表的研究证明了miR-145在胰腺癌中的临床意义，并表明miR-145在人类胰腺肿瘤中的失调与致癌粘蛋白MUC 13的异常表达平行。这些研究还提出了一种新的治疗策略，通过纳米颗粒介导的有效递送系统恢复胰腺癌中下调的miR-145水平。
Emergence of the role of MicroRNA-145 (miR-145) as a tumor suppressor in pancreatic cancer, offers its potential for novel therapeutic interventions. Our recently published studies demonstrate clinical significance of miR-145 in pancreatic cancer and suggest that the dysregulation of miR-145 in human pancreatic tumors draws in parallel with the aberrant expression of an oncogenic mucin, MUC13. These studies also present a novel therapeutic strategy of restoring the downregulated levels of miR-145 in pancreatic cancer via nanoparticle mediated efficient delivery system.