Diverse functions with a common regulator: Ubiquitin takes command of an AAA ATPase
Diverse functions with a common regulator: Ubiquitin takes command of an AAA ATPase
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DOI：
10.1016/j.jsb.2006.01.005
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发表时间：
2006-10-01
影响因子：
3
通讯作者：
Ye, Yihong
中科院分区：
文献类型：
--
作者：
Ye, Yihong
Cdc 48/p97是AAA（ATPase associated with various cellular activities）ATPase家族的成员，参与多种细胞途径，包括膜融合、蛋白质折叠/解折叠、蛋白水解依赖的转录调控、蛋白质降解和纺锤体解体。Cdc 48/p97如何执行如此多样的功能尚不清楚，但最近建立的泛素化系统的组件和各种p97活动之间的联系表明，这些看似无关的过程由Cdc 48/p97介导的可能都是由泛素。爱思唯尔公司出版
Cdc48/p97, a member of the AAA (ATPase associated with various cellular activities) ATPase family, participates in various cellular pathways including membrane fusion, protein folding/unfolding, proteolysis-dependent transcriptional control, protein degradation, and spindle disassembly. How Cdc48/p97 can perform such diverse functions is unclear, but the recently established connection between components of the ubiquitination system and various p97 activities suggests that these seemingly unrelated processes mediated by Cdc48/p97 may all be governed by ubiquitin. Published by Elsevier Inc.