Circular RNAs as novel potential biomarkers for pancreatic cancer.
Circular RNAs as novel potential biomarkers for pancreatic cancer.
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DOI：
10.7150/jca.58640
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发表时间：
2021
影响因子：
3.9
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Liu S;Li Q;Ma Y;Corpe C;Wang J
胰腺癌（PaCa）是美国癌症相关死亡的第四大原因，这些恶性肿瘤中的绝大多数是胰腺导管腺癌（PDAC），但仍然缺乏PaCa的早期检测生物标志物。与线性RNA不同，circRNA形成共价闭合的连续环，并且可以充当哺乳动物基因调节剂。它们可能成为某些肿瘤的诊断或预测性生物标志物，也可能成为不同疾病的潜在治疗靶点。本文综述了circRNA、RNA结合蛋白（RBP）及其互补序列的生物学起源; circRNA与miRNA相互作用的特征; circRNA在基因表达、细胞行为和肿瘤中的调控作用，及其作为胰腺癌新的生物标志物和治疗靶点的潜力。
Pancreatic cancer (PaCa) is the fourth leading cause of cancer-related deaths in the United States, and the vast majority of these malignancies are pancreatic ductal adenocarcinomas (PDAC), but there is still a lack of early detection biomarkers for PaCa. Unlike linear RNAs, circRNAs form covalently closed continuous loops and can act as mammalian gene regulators. They may be diagnostic or predictive biomarkers for some tumors, also be novel potential therapeutic targets in different diseases. This review focuses on (1) the biogenesis of circRNAs, RNA binding proteins (RBPs) and complementary sequences of circRNAs; (2) the characteristics of circRNAs which allow them to interact with miRNAs; (3) the roles of circRNAs playing in the regulation of gene expression, cell behavior and cancer, and their potential role as novel biomarkers and therapeutic targets in pancreatic cancer.
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影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
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影响因子：
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DOI：
10.1186/s13046-019-1436-0
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