Antiviral activity of (+)-sattabacin against varicella zoster
Antiviral activity of (+)-sattabacin against varicella zoster
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DOI：
10.1016/j.bmcl.2012.11.017
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发表时间：
2013-01-15
影响因子：
2.7
通讯作者：
Blake, David J.
中科院分区：
文献类型：
--
作者：
Mancha, Serena R.;Regnery, Christopher M.;Blake, David J.
首次报道了（+）-沙他巴星对水痘-带状疱疹病毒（VZV）的抗病毒活性。我们的研究结果表明，（+）-sattabacin有效地抑制VZV的生长，在浓度范围内的其他药物通常规定的VZV感染。实验详细介绍了合成（+）-satabacin，定量的细胞毒性和基因表达数据在人成纤维细胞。通过微阵列分析从暴露于沙他巴星的人成纤维细胞获得基因表达数据，以鉴定（+）-沙他巴星抑制VZV复制的可能机制。(C)2012爱思唯尔有限公司保留所有权利。
The first report of the antiviral activity of (+)-sattabacin against varicella-zoster virus (VZV) is described. Our results show that (+)-sattabacin potently inhibits the growth of VZV at concentrations in the range of other drugs commonly prescribed for VZV infection. Experiments detailing the synthesis of (+)-sattabacin, quantification of cytotoxicity and gene expression data in human fibroblast cells are also presented. Gene expression data was obtained through microarray analysis from human fibroblast cells exposed to sattabacin in order to identify a possible mechanism by which (+)-sattabacin inhibits VZV replication. (C) 2012 Elsevier Ltd. All rights reserved.