Optical study of interactions among propagation waves of neural excitation in the rat somatosensory cortex evoked by forelimb and hindlimb stimuli
Optical study of interactions among propagation waves of neural excitation in the rat somatosensory cortex evoked by forelimb and hindlimb stimuli
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前肢和后肢刺激引起的大鼠体感皮层神经兴奋传播波相互作用的光学研究
DOI：
10.1152/jn.00904.2017
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发表时间：
2018
影响因子：
2.5
通讯作者：
Hirota Akihiko
中科院分区：
文献类型：
--
作者：
Hama Noriyuki;Kawai Minako;Ito Shin-Ichi;Hirota Akihiko
多点光学记录表明，感觉刺激引起的神经兴奋波从焦点开始并在皮层中传播。这种波被认为对于感觉皮层的计算很重要，特别是感觉信息的整合；然而，这一波的性质仍然很大程度上未知。在本研究中，我们检查了具有不同刺激间隔的后肢和前肢刺激引起的大鼠感觉皮层中两个波之间的相互作用。我们将所得模式分类如下：1）两个波的碰撞，2）前肢诱导波通过后肢焦点时诱发后肢反应，3）前肢诱发波通过后肢焦点后诱发后肢反应。在模式 1 中，两个波融合成一个波，但传播模式与两个单独引起的传播过程叠加所预测的不同。在模式2中，两个波之间的相互作用的状态根据构成后肢焦点周围的前肢感应波的光信号的相位而变化。虽然在上升阶段没有观察到后肢诱发波，但前肢诱发波的传播速度增加。在峰值时，既没有检测到后肢诱导的反应，也没有检测到对前肢诱导波的调节作用。在模式 3 中，后肢诱发的波显示出幅度和空间范围减小。这些结果表明，波之间相互作用的状态受到感觉输入的相对时间的强烈影响。新的和值得注意的感觉刺激引起的皮层兴奋作为波传播并传播到感觉皮层的广阔区域。为了阐明这种相对未知现象的特征，我们检查了体感皮层中两个单独感应的波之间的相互作用。要么是波浪相互碰撞，要么是前一波浪影响了后一波浪的出现。我们的结果表明，相互作用的状态受到感官输入的相对时间的强烈影响。
Multisite optical recording has revealed that the neural excitation wave induced by a sensory stimulation begins at a focus and propagates in the cortex. This wave is considered to be important for computation in the sensory cortex, particularly the integration of sensory information; however, the nature of this wave remains largely unknown. In the present study, we examined the interaction between two waves in the rat sensory cortex induced by hindlimb and forelimb stimuli with different interstimulus intervals. We classified the resultant patterns as follows:1) the collision of two waves,2) the hindlimb response being evoked while the forelimb-induced wave is passing the hindlimb focus, and3) the hindlimb response being evoked after the forelimb-induced wave has passed the hindlimb focus. Inpattern 1, the two waves fused into a single wave, but the propagation pattern differed from that predicted by the superimposition of two singly induced propagation courses. Inpattern 2, the state of the interaction between the two waves varied depending on the phase of optical signals constituting the forelimb-induced wave around the hindlimb focus. Although no hindlimb-induced wave was observed in the rising phase, the propagating velocity of the forelimb-induced wave increased. At the peak, neither the hindlimb-induced response nor a modulatory effect on the forelimb-induced wave was detected. Inpattern 3, the hindlimb-induced wave showed a reduced amplitude and spatial extent. These results indicate that the state of the interaction between waves was strongly influenced by the relative timing of sensory inputs.NEW & NOTEWORTHYSensory stimulation-induced cortical excitation propagates as a wave and spreads over a wide area of the sensory cortex. To elucidate the characteristics of this relatively unknown phenomenon, we examined the interaction between two individually induced waves in the somatosensory cortex. Either the waves collided or the preceding wave affected the emergence of the following one. Our results indicate that the state of the interaction was strongly influenced by the relative timing of sensory inputs.