Clinical significance of increased plasma concentration of macrophage colony-stimulating factor in patients with angina pectoris.
Clinical significance of increased plasma concentration of macrophage colony-stimulating factor in patients with angina pectoris.
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DOI：
10.1016/s0735-1097(99)00583-5
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发表时间：
2000-03
影响因子：
24
通讯作者：
T. Saitoh;Hiroshi Kishida;Yayoi Tsukada;Yumiko Fukuma;Junko Sano;M. Yasutake;N. Fukuma;Yoshiki Kusama;Hirokazu Hayakawa
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文献类型：
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作者：
T. Saitoh;Hiroshi Kishida;Yayoi Tsukada;Yumiko Fukuma;Junko Sano;M. Yasutake;N. Fukuma;Yoshiki Kusama;Hirokazu Hayakawa
为了确定巨噬细胞集落刺激因子（MCSF）在冠状动脉疾病（CAD）患者动脉粥样硬化形成中的作用，我们评估了血浆MCSF浓度与CAD患者急性冠状动脉事件发生率之间的关系。然而，MCSF对CAD患者临床病程的影响尚不清楚。方法：我们测定了142例有记录的CAD患者（62 ± 9岁）的血浆MCSF浓度，并进行了平均14 ± 6个月的随访。该研究包括97例稳定型心绞痛（SA）患者，45例不稳定型心绞痛（UA）患者和22例年龄匹配的对照组。UA患者血浆MCSF浓度显著高于SA患者和对照组（981 ± 277 vs.693 ± 223 vs.680 ± 158 pg/ml，p < 0.001）。20例有冠状动脉事件的患者的平均血浆MCSF浓度显著高于无冠状动脉事件的患者（1，192 ± 232 vs. 690 ± 213 pg/ml，p < 0.001）。不利结果的预测因子是MCSF浓度的增加，CAD的存在和低射血分数。CONCLUSIONSThese研究结果表明，增加循环MCSF浓度反映了CAD患者动脉粥样硬化的进展，并预测未来的心脏事件。
OBJECTIVESTo determine the effect of macrophage colony–stimulating factor (MCSF) on atherogenesis in patients with coronary artery disease (CAD), we assessed the relation between the plasma concentration of MCSF and the incidence of acute coronary events in patients with CAD.BACKGROUNDCytokines such as MCSF play a central role in inflammatory and proliferative responses in patients with acute coronary syndromes. However, the effect of MCSF on the clinical course in patients with CAD is still not known.METHODSWe measured the plasma MCSF concentration in 142 patients with documented CAD (62 ± 9 years) and followed up for a mean period of 14 ± 6 months. The study included 97 patients with stable angina (SA), 45 patients with unstable angina (UA) and 22 age-matched control subjects. The predictors of coronary events were analyzed by using a Cox proportional hazards model.RESULTSThe mean plasma MCSF concentration in patients with UA was significantly higher than that in patients with SA and in control subjects (981 ± 277 vs. 693 ± 223 vs. 680 ± 158 pg/ml, p < 0.001). The mean plasma MCSF concentration in the 20 patients with coronary events was significantly higher than that in patients without coronary events (1,192 ± 232 vs. 690 ± 213 pg/ml, p < 0.001). The predictors of unfavorable outcome were an increased MCSF concentration, the presence of CAD and a low ejection fraction.CONCLUSIONSThese findings suggest that an increased circulating MCSF concentration reflects atherosclerotic progression in patients with CAD and predicts future cardiac events.