Chemosensitivity differences between primary and metastatic lesions of clinical gastric cancer.
Chemosensitivity differences between primary and metastatic lesions of clinical gastric cancer.
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临床胃癌原发灶和转移灶化疗敏感性差异。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
K. Sugimachi
中科院分区：
文献类型：
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作者：
H. Kusumoto;Y. Maehara;T. Kusumoto;H. Anai;K. Akazawa;K. Sugimachi
采用琥珀酸脱氢酶抑制试验(SDI)对16对临床胃癌原发灶和转移灶标本进行体外药敏试验。淋巴结转移11例，肝转移5例。转移灶对卡介苗(CQ)、阿霉素(ADM)、丝裂霉素C(MMC)、阿克拉霉素A(ACR)、5-氟尿嘧啶(5-FU)等6种抗癌药物的敏感性与原发灶不同，除DDP外，原发灶与转移灶对上述药物的敏感性无相关性。淋巴结对CQ、ADM、MMC、DDP、ACR和5-FU的敏感性较高，而肝脏对CQ、ADM、MMC、DDP和ACR的敏感性较低。我们的发现表明，在有淋巴结转移的患者中，对抗肿瘤药物是敏感的，而在肝转移的情况下，药物治疗可能不那么有效。我们建议，在尝试设计抗肿瘤药物时，应该进行化疗敏感性测试。
An in vitro chemosensitivity test, the succinate dehydrogenase inhibition (SDI) test, was used to examine 16 pairs of samples obtained simultaneously from primary and metastatic lesions of clinical gastric cancer. Concerning the metastases, 11 were in the lymph nodes and five in the liver. The chemosensitivities of metastatic lesions against six anti-tumour drugs, carboquone (CQ), adriamycin (ADM), mitomycin C (MMC), aclacinomycin A (ACR), and 5-fluorouracil (5-FU), differed from those in the primary lesions, and there were no correlations of chemosensitivities between the primary and the metastatic lesions against these drugs, except for DDP. The lymph nodes were more sensitive to CQ, ADM, MMC, DDP, ACR and 5-FU, while the liver was less sensitive than the primary lesions to CQ, ADM, MMC, DDP, and ACR. Our findings indicate that in patients with lymph node metastasis, there is a sensitivity to anti-tumour drugs, while in cases of liver metastasis, drug treatment may be less effective. We propose that chemosensitivity testing should be done when attempting to design anti-tumour drugs.