Bioavailability of Bioactive Molecules from Olive Leaf Extracts and its Functional Value
Bioavailability of Bioactive Molecules from Olive Leaf Extracts and its Functional Value
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DOI：
10.1002/ptr.5625
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发表时间：
2016-07-01
影响因子：
7.2
通讯作者：
Delgado-Adamez, Jonathan
中科院分区：
文献类型：
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作者：
Martin-Vertedor, Daniel;Garrido, Maria;Delgado-Adamez, Jonathan
橄榄叶是生物活性化合物的重要低成本来源。本研究旨在研究橄榄叶水提取物体外消化率的影响，以证明其酚类化合物的有效性以及模拟消化过程后的抗氧化、抗菌和抗癌活性。纯冻干提取物中的总酚含量显着较高。然而，模拟胃液 (SGF) 和模拟肠液 (SIF) 中的酚类化合物分别减少了 60% 和 90%。抗氧化活性经胃和肠消化后分别降低10%和50%；尽管如此，SGF 和 SIF 均具有较高的抗氧化能力。此外，橄榄叶提取物在低浓度下表现出不寻常的联合抗菌作用，这表明它们作为营养保健品的巨大潜力，特别是作为酚类化合物的来源。最后，橄榄叶提取物对 U937 细胞产生一般剂量依赖性细胞毒性作用。总而言之，这些研究结果表明，橄榄叶水提取物在模拟消化过程后仍保持其有益特性，因此定期食用可能有助于管理和预防与氧化应激相关的慢性疾病、细菌感染甚至癌症。版权所有 (c) 2016 约翰·威利父子有限公司
Olive leaves are an important low-cost source of bioactive compounds. The present study aimed to examine the effect of in vitro digestibility of an olive leaf aqueous extract so as to prove the availability of its phenolic compounds as well as its antioxidant, antimicrobial, and anticancer activity after a simulated digestion process. The total phenolic content was significantly higher in the pure lyophilized extract. Phenolic compounds, however, decreased by 60% and 90% in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively. Regarding antioxidant activity, it was reduced by 10% and 50% after gastric and intestinal digestion, respectively; despite this fact, high antioxidant capacity was found in both SGF and SIF. Moreover, the olive leaf extract showed an unusual combined antimicrobial action at low concentration, which suggested their great potential as nutraceuticals, particularly as a source of phenolic compounds. Finally, olive leaf extracts produced a general dose-dependent cytotoxic effect against U937 cells. To sum up, these findings suggest that the olive leaf aqueous extract maintains its beneficial properties after a simulated digestion process, and therefore its regular consumption could be helpful in the management and the prevention of oxidative stress-related chronic disease, bacterial infection, or even cancer. Copyright (c) 2016 John Wiley & Sons, Ltd.