Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells
Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells
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DOI：
10.1016/j.canlet.2003.10.024
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发表时间：
2004-03-31
期刊：
影响因子：
9.7
通讯作者：
Kisielow, P
中科院分区：
文献类型：
--
作者：
Cebrat, M;Strzadala, L;Kisielow, P
应用cDNA代表性差异分析发现，OPG、CTSE、Krt2-4、Fut-2、24p3和WiF-1基因在肠腺瘤中的表达均高于APC(Min/+)突变小鼠正常肠上皮细胞。编码Wnt抑制因子-1的WiF-1在许多上皮细胞来源的肿瘤细胞系中也被检测到，包括两个人结肠腺癌细胞系。本文还讨论了WiF-1过表达在结直肠癌发病机制中的可能作用。(C)2003爱思唯尔爱尔兰有限公司。保留所有权利。
Using cDNA-Representational Difference Analysis it was found that expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc(Min/+) mutant mice. Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines. The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed. (C) 2003 Elsevier Ireland Ltd. All rights reserved.