Constituents of Chrysothamnus viscidiflorus
Constituents of Chrysothamnus viscidiflorus
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DOI：
10.1016/j.phytochem.2006.03.021
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发表时间：
2006-07-01
期刊：
影响因子：
3.8
通讯作者：
Mabry, Tom J.
中科院分区：
文献类型：
--
作者：
Ahmed, Ahmed A.;Hegazy, Mohamed-Elamir F.;Mabry, Tom J.
Chrysothamnus viscidiflorus var. 地上部分的植物化学研究viscidiflorus 提供了三种新的[chrysothol (1)、2 和 4] 和七种已知化合物，包括五种倍半萜烯、两种肉桂酸衍生物、两种酮醇衍生物和一种香豆素葡萄糖苷。先前报道的两种化合物1b和1c的结构在化学反应的基础上进行了修改。化合物的结构通过广泛的 NMR 研究确定，包括 DEPT、COSY、NOE、HMQC、HMBC 和 X 射线分析。报告了已知化合物 6 和 7 的未发表的 X 射线数据。化合物chrysothol (1) 和8-10 对人类乳腺癌细胞显示出抗癌活性。 (c) 2006 Elsevier Ltd. 保留所有权利。
A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [chrysothol (1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported. Compounds chrysothol (1), and 8-10 showed anti-cancer activity against human breast cancer cells. (c) 2006 Elsevier Ltd. All rights reserved.