Newly Emerging Clones of Bordetella pertussis Carrying prn2 and ptxP3 Alleles Implicated in Australian Pertussis Epidemic in 2008-2010
Newly Emerging Clones of Bordetella pertussis Carrying prn2 and ptxP3 Alleles Implicated in Australian Pertussis Epidemic in 2008-2010
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DOI：
10.1093/infdis/jis178
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发表时间：
2012-04-15
影响因子：
6.4
通讯作者：
Lan, Ruiting
中科院分区：
文献类型：
--
作者：
Octavia, Sophie;Sintchenko, Vitali;Lan, Ruiting
澳大利亚正在经历一场始于2008年的长期百日咳流行病。通过单核苷酸多态性（SNP）分析、多位点可变数目串联重复序列分析以及fim3、prn和ptxP序列分析，对2008年至2010年收集的194株百日咳博德特氏菌分离株进行分型。具有来自最近出现的SNP簇I的携带prn2和ptxP3的2个密切相关的SNP谱的菌株占优势。这些数据表明，在B中的选择越来越多。在无细胞疫苗诱导的免疫力的压力下，澳大利亚的百日咳人群有利于携带prn 2和ptxP3的菌株。
Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.