Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways.
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways.
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DOI：
10.1042/cs20220572
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发表时间：
2022-09-30
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代谢相关脂肪肝病 (MAFLD) 是一种肝脏脂肪堆积并伴有超重或肥胖和胰岛素抵抗等代谢功能障碍的疾病。它还与心血管疾病风险增加有关，包括高血压和动脉粥样硬化。肝脏脂质代谢通过脂肪酸的摄取和输出、从头脂肪生成以及通过β-氧化的脂肪利用的组合来调节。当这些途径之间的平衡被改变时，肝脏脂质开始积累，炎症和纤维化途径的长期激活可能会导致肝脏疾病恶化。这篇综述讨论了调节肝脂质的分子机制的细节以及针对这些途径的新兴疗法作为 MAFLD 的未来潜在治疗方法。
The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance. It is also associated with an increased cardiovascular disease risk, including hypertension and atherosclerosis. Hepatic lipid metabolism is regulated by a combination of the uptake and export of fatty acids, de novo lipogenesis, and fat utilization by β-oxidation. When the balance between these pathways is altered, hepatic lipid accumulation commences, and long-term activation of inflammatory and fibrotic pathways can progress to worsen the liver disease. This review discusses the details of the molecular mechanisms regulating hepatic lipids and the emerging therapies targeting these pathways as potential future treatments for MAFLD.