Chronotherapy using corticosteroids for multiple sclerosis relapses
Chronotherapy using corticosteroids for multiple sclerosis relapses
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DOI：
10.1136/jnnp.2006.104000
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发表时间：
2007-08-01
影响因子：
11
通讯作者：
Miller, Ariel
中科院分区：
文献类型：
--
作者：
Glass-Marmor, Lea;Paperna, Tamar;Miller, Ariel
背景：免疫系统的活动具有昼夜节律。在疾病的特点是异常的免疫活动，时间疗法（治疗方案量身定制的昼夜身体节律）可能会增加的效率，安全性和耐受性的drugs.Aim：比较结果的静脉注射皮质类固醇给药在白天或晚上，急性多发性硬化症复发的治疗方法：17例多发性硬化症患者被列入研究。在试验入组时以及治疗开始后第7天和第30天进行残疾的临床评估。不良事件和夜间与日间治疗的偏好进行了评估，在治疗course.Results结束时：夜间治疗后，临床恢复显着（p < 0.001）增强和副作用的平均数显着（p = 0.007）较低。此外，大多数患者表示，夜间与白天treatment.Conclusions的偏好：这项研究表明，使用类固醇治疗急性多发性硬化症复发的时间疗法的实施的潜在好处，与其他免疫介导的疾病的影响。
Background: The activity of the immune system displays a circadian rhythm. In diseases characterised by aberrant immune activity, chronotherapy ( a treatment regimen tailored to diurnal body rhythms) may increase the efficiency, safety and tolerability of drugs.Aim: To compare the outcomes of intravenous corticosteroid administration during the day or night, for treatment of acute multiple sclerosis relapses.Methods: 17 patients with multiple sclerosis were included in the study. Clinical assessment of disability was performed at trial entry, and at days 7 and 30 from the initiation of treatment. Adverse events and preference of night-time versus daytime treatment were assessed at the end of the treatment course.Results: After night-time treatment, clinical recovery was significantly (p < 0.001) enhanced and the mean number of side effects was significantly (p = 0.007) lower. Furthermore, most patients expressed a preference for night-time versus daytime treatment.Conclusions: The study suggests a potential benefit for implementation of chronotherapy using steroid treatment for acute multiple sclerosis relapse, with implications for other immune-mediated disorders.