Optimal antibiotic therapy in cholera.
Optimal antibiotic therapy in cholera.
复制标题
霍乱的最佳抗生素治疗。
DOI：
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发表时间：
1968
影响因子：
11.1
通讯作者：
R. Waldman
中科院分区：
文献类型：
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作者：
C. K. Wallace;P. N. Anderson;T. Brown;S. Khanra;G. W. Lewis;N. F. Pierce;S. Sanyal;G. Segre;R. Waldman
通过静脉补充体液和电解质以恢复生理水合状态是成功治疗霍乱患者的基础。使用口服四环素作为减少腹泻量和持续时间以及根除胃肠道弧菌的辅助手段已被证明是有益的。之前尚未确定最佳剂量方案，并且通常报告了临床或细菌学复发。氯霉素和磺胺胍也被提到作为抗生素。本报告显示，3个给药方案之一的3 g或4 g四环素可预测有效。氯霉素虽然有益处，但效果不佳，与四环素方案相比，磺胺胍的益处不大。
Intravenous replacement of the diarrhoeal fluid and electrolyte losses to restore a physiological state of hydration is well established as the basis for successful management of cholera patients. The use of oral tetracycline as an adjunct in reducing the volume and duration of diarrhoea, as well as eradicating the vibrio from the gastrointestinal tract, has been proven beneficial. An optimal dose schedule has not been established previously, and clinical or bacteriological relapses have been generally reported. Chloramphenicol and sulfaguanidine have also been mentioned as adjuncts. The present report shows that 3 g or 4 g of tetracycline in one of 3 dose schedules were predictably efficacious. Chloramphenicol, while of benefit, was not as effective and sulfaguanidine was of little benefit compared with the tetracycline regimens.