Getting lost: Topographic skills in acquired and developmental prosopagnosia.
Getting lost: Topographic skills in acquired and developmental prosopagnosia.
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DOI：
10.1016/j.cortex.2016.01.003
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Barton JJS
中科院分区：
文献类型：
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作者：
Corrow JC;Corrow SL;Lee E;Pancaroglu R;Burles F;Duchaine B;Iaria G;Barton JJS
以往的研究报告，获得性面容失认症是经常与地形定向障碍。这是否与特定的解剖亚型的面容失认症，它是如何频繁地看到与发展的变异，以及什么特定的地形功能受损，以解释这个问题是未知的。我们研究了10名受试者获得性面孔失认症无论是枕颞或前颞病变和7个发展性面孔失认症。受试者接受了一系列地形测试，包括房屋和场景识别、道路图测试、认知地图形成测试和标准化自我报告问卷。在获得性面容失认症中，无论是枕颞还是前颞病变，房屋和/或场景识别经常受损。枕颞叶病变的受试者在认知地图形成方面也受损：重叠分析确定右侧梭状回和海马旁回可能相关。只有一个获得性面容失认症的主题有轻微的困难，方向定位的路线图测试。只有一名患有发展性面容失认症的受试者在认知地图形成方面有困难，其他测试都没有受损。房子和场景识别的分数与问卷调查的结果相关性最强。我们的结论是，地形定向障碍在获得性面孔失认症反映受损的地方识别，从不良的认知地图形成时，有枕颞损伤的贡献。地形障碍较少发生在发展性面容失认症。
Previous studies report that acquired prosopagnosia is frequently associated with topographic disorientation. Whether this is associated with a specific anatomic subtype of prosopagnosia, how frequently it is seen with the developmental variant, and what specific topographic function is impaired to account for this problem are not known. We studied ten subjects with acquired prosopagnosia from either occipitotemporal or anterior temporal lesions and seven with developmental prosopagnosia. Subjects were given a battery of topographic tests, including house and scene recognition, the road map test, a test of cognitive map formation, and a standardized self-report questionnaire. House and/or scene recognition were frequently impaired after either occipitotemporal or anterior temporal lesions in acquired prosopagnosia. Subjects with occipitotemporal lesions were also impaired in cognitive map formation: an overlap analysis identified right fusiform and parahippocampal gyri as a likely correlate. Only one subject with acquired prosopagnosia had mild difficulty with directional orientation on the road map test. Only one subject with developmental prosopagnosia had difficulty with cognitive map formation, and none were impaired on the other tests. Scores for house and scene recognition correlated most strongly with the results of the questionnaire. We conclude that topographic disorientation in acquired prosopagnosia reflects impaired place recognition, with a contribution from poor cognitive map formation when there is occipitotemporal damage. Topographic impairments are less frequent in developmental prosopagnosia.